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- W2034854039 abstract "Abstract Diets containing the antioxidant ethoxyquin (6-ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline) were fed to female CD-1 mice for 10–38 days to assess their effects on monocrotaline toxicity, liver glutathione levels and hepatic drug metabolizing enzyme activities. Dietary ethoxyquin (0.25%) protected the mice against lethality as well as acute hepatotoxicity of monocrotaline as measured by the levels of alanine aminotransferase and asparate aminotransferase in plasma. Other feed additives with antioxidant properties such as vitamin C, vitamin E or selenium had no protective effect against monocrotaline lethality and hepatotoxicity. Dietary cysteine (1%) also protected mice against the lethality but not the acute hepatotoxicity of the alkaloid. With the exception of ethoxyquin, none of the other feed additives increased liver glutathione levels (mg/liver). Glutathione S-transferase activity was significantly increased by either dietary ethoxyquin or cysteine using chlorodinitrobenzene as substrate. Dietary ethoxyquin produced an increase in hepatic cytochrome P-450 content and an increase in the in vitro conversion of monocrotaline to pyrrole metabolites by liver microsomes. However, there was no effect of the feed additive on the activity of aminopyrine demethylase and on the concentration of pyrroles found in the liver 2 or 24 h after monocrotaline administration. Since ethoxyquin protected mice against monocrotaline lethality and hepatotoxicity despite no reduction in the in vivo activation of monocrotaline, the mechanisms involved are most probably a result of increased detoxication processes partly because of increased liver glutathione levels." @default.
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- W2034854039 date "1981-10-01" @default.
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- W2034854039 title "Effect of ethoxyquin on the toxicity of the pyrrolizidine alkaloid monocrotaline and on hepatic drug metabolism in mice" @default.
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- W2034854039 doi "https://doi.org/10.1016/0009-2797(81)90168-x" @default.
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