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• W2034854728 startingPage "381" @default.
• W2034854728 abstract "<i>Spock3/Testican-3 </i>is a nervous system-expressed heparan sulfate proteoglycan belonging to a subgroup of the BM-40/SPARC/osteonectin family, the role of which in brain development is unclear. Because <i>Spock1</i>, a member of the <i>Spock </i>family, inhibits their attachment to substrates and the neurite outgrowth of cultured neuronal cells, <i>Spock3 </i>is also thought to be similarly involved in the neuronal development. In the present study, we established a <i>Spock3-</i>mutant mouse harboring a deletion extending from the presumptive upstream regulatory region to exon 4 of the <i>Spock3 </i>locus and performed histological and behavioral studies on these mutant mice. In wild-type (WT) mice, all <i>Spock </i>members were clearly expressed during brain development. In adults, intense <i>Spock1 </i>and <i>Spock2 </i>expressions were observed throughout the entire brain; whereas, <i>Spock3 </i>expression was no longer visible except in the thalamic nuclei. Thus, <i>Spock3 </i>expression is mostly confined to the developmental stage of the brain. In adult mutant mice, the cells of all cortical layers were swollen. The corpus callosum was narrowed around the central region along the rostral-caudal axis and many small spaces were observed without myelin sheaths throughout the entire corpus callosum. In addition, the cortical input and output fibers did not form into thick bundled fibers as well as the WT counterparts did. Moreover, a subpopulation of corticospinal axonal fibers penetrated into the dorsal striatum with moderately altered orientations. Consistent with these modifications of brain structures, the mutant mice exhibited decreased anxiety-like behavior and lowered sociability. Together, these results demonstrate that <i>Spock3 </i>plays an important role in the formation or maintenance of major neuronal structures in the brain." @default.
• W2034854728 created "2016-06-24" @default.
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• W2034854728 date "2014-01-01" @default.
• W2034854728 modified "2023-09-23" @default.
• W2034854728 title "Structural Abnormalities of Corpus Callosum and Cortical Axonal Tracts Accompanied by Decreased Anxiety-Like Behavior and Lowered Sociability in Spock3-Mutant Mice" @default.
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• W2034854728 doi "https://doi.org/10.1159/000363101" @default.
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