Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034855022> ?p ?o ?g. }
- W2034855022 endingPage "126" @default.
- W2034855022 startingPage "117" @default.
- W2034855022 abstract "Alcohol consumption is one of the most problematic and widespread forms of risk taking in adolescence. It has been hypothesized that sex hormones such as testosterone play an important role in risk taking by influencing the development of brain networks involved in emotion and motivation, particularly the amygdala and its functional connections. Connectivity between the amygdala and the orbitofrontal cortex (OFC) may be specifically related to alcohol use, given the association of this tract with top-down control over behavioral approach tendencies. In line with this, prior studies in adults indicate a link between alcohol use and functional connectivity between the amygdala and the orbitofrontal cortex (OFC), as well as between testosterone and amygdala–OFC connectivity. We consolidated these research lines by investigating the association between alcohol use, testosterone and resting state functional brain connectivity within one large-scale adolescent sample (n = 173, aged 12–25 years). Mediation analyses demonstrated an indirect effect of testosterone levels on alcohol use through amygdala–OFC intrinsic functional connectivity, but only in boys. That is, increased testosterone in boys was associated with reduced amygdala–OFC connectivity, which in turn was associated with increased alcohol intake. This study is the first to demonstrate the interplay between adolescent alcohol use, sex hormones and brain mechanisms, thus taking an important step to increase our understanding of the mechanisms behind this form of adolescent risk-taking." @default.
- W2034855022 created "2016-06-24" @default.
- W2034855022 creator A5016971492 @default.
- W2034855022 creator A5064580768 @default.
- W2034855022 creator A5078158094 @default.
- W2034855022 creator A5082064856 @default.
- W2034855022 creator A5085136481 @default.
- W2034855022 date "2015-03-01" @default.
- W2034855022 modified "2023-10-15" @default.
- W2034855022 title "The link between testosterone and amygdala–orbitofrontal cortex connectivity in adolescent alcohol use" @default.
- W2034855022 cites W1715619412 @default.
- W2034855022 cites W1970695058 @default.
- W2034855022 cites W1973688510 @default.
- W2034855022 cites W1975179643 @default.
- W2034855022 cites W1977010591 @default.
- W2034855022 cites W1984111197 @default.
- W2034855022 cites W1995031937 @default.
- W2034855022 cites W2006763459 @default.
- W2034855022 cites W2006819294 @default.
- W2034855022 cites W2007605511 @default.
- W2034855022 cites W2008852204 @default.
- W2034855022 cites W2012456149 @default.
- W2034855022 cites W2015455914 @default.
- W2034855022 cites W2016899938 @default.
- W2034855022 cites W2018102971 @default.
- W2034855022 cites W2022616811 @default.
- W2034855022 cites W2023750310 @default.
- W2034855022 cites W2025832022 @default.
- W2034855022 cites W2032477105 @default.
- W2034855022 cites W2032645175 @default.
- W2034855022 cites W2033500251 @default.
- W2034855022 cites W2038702827 @default.
- W2034855022 cites W2039817145 @default.
- W2034855022 cites W2043985159 @default.
- W2034855022 cites W2048345897 @default.
- W2034855022 cites W2050581082 @default.
- W2034855022 cites W2052515792 @default.
- W2034855022 cites W2068719957 @default.
- W2034855022 cites W2071881327 @default.
- W2034855022 cites W2074932610 @default.
- W2034855022 cites W2075943992 @default.
- W2034855022 cites W2077041443 @default.
- W2034855022 cites W2077708615 @default.
- W2034855022 cites W2078899394 @default.
- W2034855022 cites W2084335923 @default.
- W2034855022 cites W2085971650 @default.
- W2034855022 cites W2088180824 @default.
- W2034855022 cites W2089244139 @default.
- W2034855022 cites W2090682671 @default.
- W2034855022 cites W2102724049 @default.
- W2034855022 cites W2104057213 @default.
- W2034855022 cites W2106161084 @default.
- W2034855022 cites W2107167540 @default.
- W2034855022 cites W2109181684 @default.
- W2034855022 cites W2112935711 @default.
- W2034855022 cites W2113746812 @default.
- W2034855022 cites W2122419451 @default.
- W2034855022 cites W2122953373 @default.
- W2034855022 cites W2123856966 @default.
- W2034855022 cites W2128586214 @default.
- W2034855022 cites W2131568786 @default.
- W2034855022 cites W2133938203 @default.
- W2034855022 cites W2135192074 @default.
- W2034855022 cites W2143112732 @default.
- W2034855022 cites W2146828510 @default.
- W2034855022 cites W2148726987 @default.
- W2034855022 cites W2155389045 @default.
- W2034855022 cites W2155444575 @default.
- W2034855022 cites W2160326831 @default.
- W2034855022 cites W2161621299 @default.
- W2034855022 cites W2168039639 @default.
- W2034855022 cites W2169286936 @default.
- W2034855022 cites W2171280999 @default.
- W2034855022 cites W2181332675 @default.
- W2034855022 cites W4235770099 @default.
- W2034855022 doi "https://doi.org/10.1016/j.psyneuen.2015.01.004" @default.
- W2034855022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25618591" @default.
- W2034855022 hasPublicationYear "2015" @default.
- W2034855022 type Work @default.
- W2034855022 sameAs 2034855022 @default.
- W2034855022 citedByCount "75" @default.
- W2034855022 countsByYear W20348550222015 @default.
- W2034855022 countsByYear W20348550222016 @default.
- W2034855022 countsByYear W20348550222017 @default.
- W2034855022 countsByYear W20348550222018 @default.
- W2034855022 countsByYear W20348550222019 @default.
- W2034855022 countsByYear W20348550222020 @default.
- W2034855022 countsByYear W20348550222021 @default.
- W2034855022 countsByYear W20348550222022 @default.
- W2034855022 countsByYear W20348550222023 @default.
- W2034855022 crossrefType "journal-article" @default.
- W2034855022 hasAuthorship W2034855022A5016971492 @default.
- W2034855022 hasAuthorship W2034855022A5064580768 @default.
- W2034855022 hasAuthorship W2034855022A5078158094 @default.
- W2034855022 hasAuthorship W2034855022A5082064856 @default.
- W2034855022 hasAuthorship W2034855022A5085136481 @default.
- W2034855022 hasConcept C126322002 @default.
- W2034855022 hasConcept C138496976 @default.