FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034856071> ?p ?o ?g. }

• W2034856071 endingPage "32" @default.
• W2034856071 startingPage "23" @default.
• W2034856071 abstract "The development of a simple assay for studying human T and NK lymphopoiesis from CD34 progenitors is of great interest. T and NK cells arise from a common CD34+immature precursor. While T cell maturation is dependent on interactions and cytokines provided by thymic stromal cells. NK maturation does not require the thymic microenvironment and primarily takes place extrathymically. In addition to models using a mouse thymic microenvironment,in vitroassays based on coculture on human fetal thymic stroma have been described. As an alternative source of fetal thymic tissue we studied the capacity of neonatal thymic epithelial cell enriched stroma to support T and NK cell differentiation. While in the fetal-based assays on NK cells were observed under the conditions used for T cell differentiation, neonatal stroma can generate CD3/TcR+as well as CD56+3−8+NKR-P1+NK cells from both CD34+1−and CD34+1+thymocyte precursors. However, following acquisition of CD3/TcR, T-lineage cells disappeared from the culture after 2–3 weeks as a consequence of the outgrowth of the NK cells. These CD56+3−NK cells appeared to be functionally immature as they required incubation with IL2 or IL15 to lyse K562 target cells. Our data offer a simple and reliable assay for studying the reconstitution potential of T and NK cell progenitors on a monolayer of thymic epithelial cells." @default.
• W2034856071 created "2016-06-24" @default.
• W2034856071 creator A5006820876 @default.
• W2034856071 creator A5034186453 @default.
• W2034856071 creator A5038115131 @default.
• W2034856071 creator A5060855508 @default.
• W2034856071 creator A5079438343 @default.
• W2034856071 date "1998-11-01" @default.
• W2034856071 modified "2023-09-27" @default.
• W2034856071 title "Human CD34+Thymocyte Maturation: Pre-T and NK Cell Differentiation on Neonatal Thymic Stromal Cell Culture" @default.
• W2034856071 cites W1564089740 @default.
• W2034856071 cites W1564533473 @default.
• W2034856071 cites W175604019 @default.
• W2034856071 cites W1974153392 @default.
• W2034856071 cites W1976756827 @default.
• W2034856071 cites W1982163798 @default.
• W2034856071 cites W1986762586 @default.
• W2034856071 cites W1989265104 @default.
• W2034856071 cites W1996441373 @default.
• W2034856071 cites W1998363365 @default.
• W2034856071 cites W1998651301 @default.
• W2034856071 cites W2002201946 @default.
• W2034856071 cites W2010519150 @default.
• W2034856071 cites W2040735196 @default.
• W2034856071 cites W2050990545 @default.
• W2034856071 cites W2059511782 @default.
• W2034856071 cites W2106241062 @default.
• W2034856071 cites W2108207978 @default.
• W2034856071 cites W2118099290 @default.
• W2034856071 cites W2130035360 @default.
• W2034856071 cites W2131314634 @default.
• W2034856071 cites W2143048510 @default.
• W2034856071 cites W2146734212 @default.
• W2034856071 cites W2147458220 @default.
• W2034856071 cites W2147787458 @default.
• W2034856071 cites W2245244225 @default.
• W2034856071 cites W2302003442 @default.
• W2034856071 cites W2314331148 @default.
• W2034856071 cites W2322548232 @default.
• W2034856071 cites W2342876642 @default.
• W2034856071 cites W2402443265 @default.
• W2034856071 cites W242181897 @default.
• W2034856071 cites W4232115098 @default.
• W2034856071 doi "https://doi.org/10.1006/cimm.1998.1378" @default.
• W2034856071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9826443" @default.
• W2034856071 hasPublicationYear "1998" @default.
• W2034856071 type Work @default.
• W2034856071 sameAs 2034856071 @default.
• W2034856071 citedByCount "8" @default.
• W2034856071 crossrefType "journal-article" @default.
• W2034856071 hasAuthorship W2034856071A5006820876 @default.
• W2034856071 hasAuthorship W2034856071A5034186453 @default.
• W2034856071 hasAuthorship W2034856071A5038115131 @default.
• W2034856071 hasAuthorship W2034856071A5060855508 @default.
• W2034856071 hasAuthorship W2034856071A5079438343 @default.
• W2034856071 hasConcept C10205521 @default.
• W2034856071 hasConcept C104317684 @default.
• W2034856071 hasConcept C109159458 @default.
• W2034856071 hasConcept C114684123 @default.
• W2034856071 hasConcept C129374314 @default.
• W2034856071 hasConcept C147483822 @default.
• W2034856071 hasConcept C148738053 @default.
• W2034856071 hasConcept C167672396 @default.
• W2034856071 hasConcept C16930146 @default.
• W2034856071 hasConcept C201750760 @default.
• W2034856071 hasConcept C203014093 @default.
• W2034856071 hasConcept C2776090121 @default.
• W2034856071 hasConcept C2778954852 @default.
• W2034856071 hasConcept C28328180 @default.
• W2034856071 hasConcept C502942594 @default.
• W2034856071 hasConcept C55493867 @default.
• W2034856071 hasConcept C79904392 @default.
• W2034856071 hasConcept C86803240 @default.
• W2034856071 hasConcept C8891405 @default.
• W2034856071 hasConcept C95444343 @default.
• W2034856071 hasConceptScore W2034856071C10205521 @default.
• W2034856071 hasConceptScore W2034856071C104317684 @default.
• W2034856071 hasConceptScore W2034856071C109159458 @default.
• W2034856071 hasConceptScore W2034856071C114684123 @default.
• W2034856071 hasConceptScore W2034856071C129374314 @default.
• W2034856071 hasConceptScore W2034856071C147483822 @default.
• W2034856071 hasConceptScore W2034856071C148738053 @default.
• W2034856071 hasConceptScore W2034856071C167672396 @default.
• W2034856071 hasConceptScore W2034856071C16930146 @default.
• W2034856071 hasConceptScore W2034856071C201750760 @default.
• W2034856071 hasConceptScore W2034856071C203014093 @default.
• W2034856071 hasConceptScore W2034856071C2776090121 @default.
• W2034856071 hasConceptScore W2034856071C2778954852 @default.
• W2034856071 hasConceptScore W2034856071C28328180 @default.
• W2034856071 hasConceptScore W2034856071C502942594 @default.
• W2034856071 hasConceptScore W2034856071C55493867 @default.
• W2034856071 hasConceptScore W2034856071C79904392 @default.
• W2034856071 hasConceptScore W2034856071C86803240 @default.
• W2034856071 hasConceptScore W2034856071C8891405 @default.
• W2034856071 hasConceptScore W2034856071C95444343 @default.
• W2034856071 hasIssue "1" @default.
• W2034856071 hasLocation W20348560711 @default.
• W2034856071 hasLocation W20348560712 @default.

• next