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- W2034856094 abstract "In The Lancet Oncology, Grignani and colleagues 1 Grignani G Palmerini E Ferraresi V et al. Sorafenib and everolimus for patients with unresectable high-grade osteosarcoma progressing after standard treatment: a non-randomised phase 2 clinical trial. Lancet Oncol. 2015; 16: 98-107 Summary Full Text Full Text PDF PubMed Scopus (216) Google Scholar report the first positive study in at least 25 years in patients with relapsed osteosarcoma. Since the introduction of ifosfamide in the late 1980s, few active new regimens for these patients have been reported. The addition of etoposide to ifosfamide or cyclophosphamide has questionable value. The combination of gemcitabine and docetaxel, broadly active in soft-tissue sarcomas, has real but marginal activity against osteosarcoma, but I, and a group of experienced collaborators from the Sarcoma Alliance for Research through Collaboration, could not show its value, partly because of flawed clinical trial design. 2 Fox E Patel S Wathen JK et al. Phase II study of sequential gemcitabine followed by docetaxel for recurrent Ewing sarcoma, osteosarcoma, or unresectable or locally recurrent chondrosarcoma: results of Sarcoma Alliance for Research through Collaboration Study 003. Oncologist. 2012; 17: 321 Crossref PubMed Scopus (84) Google Scholar Sorafenib and everolimus for patients with unresectable high-grade osteosarcoma progressing after standard treatment: a non-randomised phase 2 clinical trialAlthough the combination of sorafenib and everolimus showed activity as a further-line treatment for patients with advanced or unresectable osteosarcoma, it did not attain the prespecified target of 6 month PFS of 50% or greater. Full-Text PDF" @default.
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- W2034856094 date "2015-01-01" @default.
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- W2034856094 title "Osteosarcoma: better treatment through better trial design" @default.
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- W2034856094 doi "https://doi.org/10.1016/s1470-2045(14)71186-6" @default.
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