FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034856420> ?p ?o ?g. }

• W2034856420 endingPage "9899" @default.
• W2034856420 startingPage "9891" @default.
• W2034856420 abstract "The incidence of malignant melanoma has dramatically increased in recent years thus requiring the need for improved therapeutic strategies. In our efforts to design selective histone deactylase inhibitors (HDACI), we discovered that the aryl urea 1 is a modestly potent yet nonselective inhibitor. Structure–activity relationship studies revealed that adding substituents to the nitrogen atom of the urea so as to generate compounds bearing a branched linker group results in increased potency and selectivity for HDAC6. Compound 5g shows low nanomolar inhibitory potency against HDAC6 and a selectivity of ∼600-fold relative to the inhibition of HDAC1. These HDACIs were evaluated for their ability to inhibit the growth of B16 melanoma cells with the most potent and selective HDAC6I being found to decrease tumor cell growth. To the best of our knowledge, this work constitutes the first report of HDAC6-selective inhibitors that possess antiproliferative effects against melanoma cells." @default.
• W2034856420 created "2016-06-24" @default.
• W2034856420 creator A5000191195 @default.
• W2034856420 creator A5006801232 @default.
• W2034856420 creator A5026395120 @default.
• W2034856420 creator A5033634359 @default.
• W2034856420 creator A5063483417 @default.
• W2034856420 creator A5082896599 @default.
• W2034856420 date "2012-10-23" @default.
• W2034856420 modified "2023-10-11" @default.
• W2034856420 title "Selective Histone Deacetylase 6 Inhibitors Bearing Substituted Urea Linkers Inhibit Melanoma Cell Growth" @default.
• W2034856420 cites W1985845937 @default.
• W2034856420 cites W1994582326 @default.
• W2034856420 cites W1995732269 @default.
• W2034856420 cites W2011828032 @default.
• W2034856420 cites W2029530310 @default.
• W2034856420 cites W2042224490 @default.
• W2034856420 cites W2052453190 @default.
• W2034856420 cites W2063078660 @default.
• W2034856420 cites W2063528655 @default.
• W2034856420 cites W2070089404 @default.
• W2034856420 cites W2077293502 @default.
• W2034856420 cites W2084849455 @default.
• W2034856420 cites W2095026025 @default.
• W2034856420 cites W2097979965 @default.
• W2034856420 cites W2111907637 @default.
• W2034856420 cites W2114553667 @default.
• W2034856420 cites W2145879583 @default.
• W2034856420 cites W2147880011 @default.
• W2034856420 cites W2162787110 @default.
• W2034856420 doi "https://doi.org/10.1021/jm301098e" @default.
• W2034856420 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3562128" @default.
• W2034856420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23009203" @default.
• W2034856420 hasPublicationYear "2012" @default.
• W2034856420 type Work @default.
• W2034856420 sameAs 2034856420 @default.
• W2034856420 citedByCount "148" @default.
• W2034856420 countsByYear W20348564202013 @default.
• W2034856420 countsByYear W20348564202014 @default.
• W2034856420 countsByYear W20348564202015 @default.
• W2034856420 countsByYear W20348564202016 @default.
• W2034856420 countsByYear W20348564202017 @default.
• W2034856420 countsByYear W20348564202018 @default.
• W2034856420 countsByYear W20348564202019 @default.
• W2034856420 countsByYear W20348564202020 @default.
• W2034856420 countsByYear W20348564202021 @default.
• W2034856420 countsByYear W20348564202022 @default.
• W2034856420 countsByYear W20348564202023 @default.
• W2034856420 crossrefType "journal-article" @default.
• W2034856420 hasAuthorship W2034856420A5000191195 @default.
• W2034856420 hasAuthorship W2034856420A5006801232 @default.
• W2034856420 hasAuthorship W2034856420A5026395120 @default.
• W2034856420 hasAuthorship W2034856420A5033634359 @default.
• W2034856420 hasAuthorship W2034856420A5063483417 @default.
• W2034856420 hasAuthorship W2034856420A5082896599 @default.
• W2034856420 hasBestOaLocation W20348564202 @default.
• W2034856420 hasConcept C104317684 @default.
• W2034856420 hasConcept C109316439 @default.
• W2034856420 hasConcept C111919701 @default.
• W2034856420 hasConcept C118792377 @default.
• W2034856420 hasConcept C161790260 @default.
• W2034856420 hasConcept C185592680 @default.
• W2034856420 hasConcept C193042331 @default.
• W2034856420 hasConcept C202751555 @default.
• W2034856420 hasConcept C23681527 @default.
• W2034856420 hasConcept C2777658100 @default.
• W2034856420 hasConcept C2778305200 @default.
• W2034856420 hasConcept C2780365088 @default.
• W2034856420 hasConcept C2780557392 @default.
• W2034856420 hasConcept C41008148 @default.
• W2034856420 hasConcept C502942594 @default.
• W2034856420 hasConcept C55493867 @default.
• W2034856420 hasConcept C57992300 @default.
• W2034856420 hasConcept C62112901 @default.
• W2034856420 hasConcept C64927066 @default.
• W2034856420 hasConcept C71924100 @default.
• W2034856420 hasConcept C86803240 @default.
• W2034856420 hasConcept C98274493 @default.
• W2034856420 hasConceptScore W2034856420C104317684 @default.
• W2034856420 hasConceptScore W2034856420C109316439 @default.
• W2034856420 hasConceptScore W2034856420C111919701 @default.
• W2034856420 hasConceptScore W2034856420C118792377 @default.
• W2034856420 hasConceptScore W2034856420C161790260 @default.
• W2034856420 hasConceptScore W2034856420C185592680 @default.
• W2034856420 hasConceptScore W2034856420C193042331 @default.
• W2034856420 hasConceptScore W2034856420C202751555 @default.
• W2034856420 hasConceptScore W2034856420C23681527 @default.
• W2034856420 hasConceptScore W2034856420C2777658100 @default.
• W2034856420 hasConceptScore W2034856420C2778305200 @default.
• W2034856420 hasConceptScore W2034856420C2780365088 @default.
• W2034856420 hasConceptScore W2034856420C2780557392 @default.
• W2034856420 hasConceptScore W2034856420C41008148 @default.
• W2034856420 hasConceptScore W2034856420C502942594 @default.
• W2034856420 hasConceptScore W2034856420C55493867 @default.
• W2034856420 hasConceptScore W2034856420C57992300 @default.
• W2034856420 hasConceptScore W2034856420C62112901 @default.
• W2034856420 hasConceptScore W2034856420C64927066 @default.
• W2034856420 hasConceptScore W2034856420C71924100 @default.

• next