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• W2034856521 abstract "We previously described the isolation of colcemid resistant Chinese hamster ovary cell lines containing α- and β-tubulin mutations that increase microtubule assembly and stability. By analyzing colcemid sensitive revertants from one of the β-tubulin mutants, we now find that loss or inactivation of the mutant allele represents the most common mechanism of reversion. Consistent with this loss, the revertants have 35% less tubulin at steady state, no evidence for the presence of a mutant polypeptide, and a normal extent of tubulin polymerization. In addition to the loss of colcemid resistance, the revertant cells exhibit increased resistance to paclitaxel relative to wild-type cells. This paclitaxel resistance can be suppressed by transfecting the revertant cells with a cDNA for wild-type β-tubulin, indicating that the reduction in tubulin in the revertant cells is responsible for the resistance phenotype. We propose that reducing tubulin levels may represent a novel mechanism of paclitaxel resistance." @default.
• W2034856521 created "2016-06-24" @default.
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• W2034856521 date "2005-06-01" @default.
• W2034856521 modified "2023-09-27" @default.
• W2034856521 title "Paclitaxel resistance in cells with reduced β-tubulin" @default.
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• W2034856521 doi "https://doi.org/10.1016/j.bbamcr.2004.12.003" @default.
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