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• W2034857725 startingPage "222" @default.
• W2034857725 abstract "Trypanosomiasis and leishmaniasis are two most ruinous parasitic infectious diseases caused by Trypanosoma and Leishmania species. The disease affects millions of people all over the world and associated with high morbidity and mortality rates. The review discuss briefly on current treatment of these parasitic diseases and trypanothione reductase (TryR) as potential targets for rational drug design. The enzyme trypanothione reductase (TryR) has been identified as unique among these parasites and has been proposed to be an effective target against for developing new drugs. The researchers have selected this enzyme as target is due to its substrate specificity in contrast to human analogous glutathione reductase and its absence from the host cell which makes this enzyme an ideal target for drug discovery. In this review we have tried to present an overview of the different tricyclic compounds which are potent inhibitors of TryR with their inhibitory activities against the parasites are briefly discussed." @default.
• W2034857725 created "2016-06-24" @default.
• W2034857725 creator A5008311077 @default.
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• W2034857725 date "2014-01-01" @default.
• W2034857725 modified "2023-09-26" @default.
• W2034857725 title "Mini review on tricyclic compounds as an inhibitor of trypanothione reductase" @default.
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• W2034857725 doi "https://doi.org/10.4103/0975-7406.142943" @default.
• W2034857725 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4231380" @default.
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