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• W2034861649 startingPage "77" @default.
• W2034861649 abstract "We studied the effect of tail pinch on male sexual behavior and its neurochemical basis. Male rats were gonadectomized and maintained on low doses of testosterone propionate (20.0 μg/day). Tail pinch significantly increased the percentage of males that mounted, intromitted, and ejaculated within a 30-min test, and these increases were attenuated by both pimozide (1.0 mg/kg, IP) and by naloxone (0.5, 1.0, and 2.0 mg/kg, SC). Moreover, tail pinch in the presence of an estrous female led to significantly increased female-directed behavior 48 h later during a test without tail pinch. Repeated tail pinch tests led to progressively more sexual activity, and the development of this behavioral sensitization was prevented by naloxone. These findings suggest that tail pinch increases the salience of the incentive characteristics of the female. Furthermore, during subsequent tests, with or without tail pinch, the increased salience of the female remains, as measured by the continued increases in sexual activity. These acute and sensitized behavioral increases might result from tail pinch-induced activation of the midbrain dopamine system via an opioid mechanism; either preventing tail pinch-induced dopamine activation (by an opioid antagonist) or blocking the effects of dopamine activation (by a dopamine antagonist) attenuated the long-term facilitation of sexual behavior seen after pairing the female with tail pinch." @default.
• W2034861649 created "2016-06-24" @default.
• W2034861649 creator A5062852231 @default.
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• W2034861649 date "1996-07-01" @default.
• W2034861649 modified "2023-10-11" @default.
• W2034861649 title "Acute and repeated activation of male sexual behavior by tail pinch: Opioid and dopaminergic mechanisms" @default.
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• W2034861649 doi "https://doi.org/10.1016/0031-9384(95)02270-8" @default.
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