FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034861882> ?p ?o ?g. }

• W2034861882 endingPage "410" @default.
• W2034861882 startingPage "401" @default.
• W2034861882 abstract "sFlt-1, a soluble secreted variant of the vascular endothelial growth factor (VEGF) receptor-1 that possesses only its extracellular domain, is a specific endogenous inhibitor of VEGF, which is involved in retinal vasculogenesis. Our objective was to determine the effects of various sFlt-1 gene fragments on retinal neovascularization in vivo using a murine oxygen-induced ischemic retinopathy (OIR) model.Lentiviral expression plasmids carrying the sFlt-1 gene fragments containing Ig-like domains 2nd-3rd and 2nd-4th were constructed. Retinal neovascularization was induced by exposing neonatal mice to hyperoxia (75% O(2)) on post-natal day 7 (P7) and then returning them to normoxia (21% O(2)) on P12. After sFlt-1 gene fragment transfer, retinal neovascularization was examined via fluorescein angiography and hematoxylin-eosin staining. In addition, changes in the expression of VEGF and its functional receptor KDR/Flk-1 were examined via Western blotting and immunohistochemistry.Lenti.sFlt-1(2-3) and lenti.sFlt-1(2-4) both significantly inhibited neovascularization in OIR mice. Retinas from mice treated with lenti.sFlt-1(2-3) demonstrated a more marked reduction in neovascular cell nuclei compared with mice treated with lenti.sFlt-1(2-4), and these results were confirmed by fluorescence angiography. Gene transfer showed a very weak effect on VEGF protein expression, whereas KDR/Flk-1 protein expression was strongly inhibited, particularly in mice treated with lenti.sFlt-1(2-3).Lentivirus-mediated sFlt-1 gene transfer significantly inhibits retinal neovascularization in OIR. Thus, sFlt-1 gene transfer may represent a potential therapeutic strategy for preventing retinal neovascularization." @default.
• W2034861882 created "2016-06-24" @default.
• W2034861882 creator A5005515378 @default.
• W2034861882 creator A5022096000 @default.
• W2034861882 creator A5046542455 @default.
• W2034861882 creator A5066353072 @default.
• W2034861882 creator A5068836221 @default.
• W2034861882 date "2009-01-01" @default.
• W2034861882 modified "2023-09-26" @default.
• W2034861882 title "Lentivirus-Mediated sFlt-1 Gene Fragment Transfer Suppresses Retinal Neovascularization" @default.
• W2034861882 cites W176812056 @default.
• W2034861882 cites W1967004211 @default.
• W2034861882 cites W1967531174 @default.
• W2034861882 cites W1986469266 @default.
• W2034861882 cites W1987362357 @default.
• W2034861882 cites W1991958278 @default.
• W2034861882 cites W1993301801 @default.
• W2034861882 cites W2002049222 @default.
• W2034861882 cites W2017887896 @default.
• W2034861882 cites W2017962415 @default.
• W2034861882 cites W2026038921 @default.
• W2034861882 cites W2028277454 @default.
• W2034861882 cites W2029521699 @default.
• W2034861882 cites W2029870078 @default.
• W2034861882 cites W2032882287 @default.
• W2034861882 cites W2049506650 @default.
• W2034861882 cites W2054154416 @default.
• W2034861882 cites W2056553905 @default.
• W2034861882 cites W2075086348 @default.
• W2034861882 cites W2089579355 @default.
• W2034861882 cites W2096454490 @default.
• W2034861882 cites W2098671787 @default.
• W2034861882 cites W2103398495 @default.
• W2034861882 cites W2121220148 @default.
• W2034861882 cites W2152293399 @default.
• W2034861882 cites W2164923772 @default.
• W2034861882 cites W2175146729 @default.
• W2034861882 cites W2253380896 @default.
• W2034861882 cites W2320241748 @default.
• W2034861882 cites W4252686797 @default.
• W2034861882 doi "https://doi.org/10.1080/02713680902862971" @default.
• W2034861882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19401884" @default.
• W2034861882 hasPublicationYear "2009" @default.
• W2034861882 type Work @default.
• W2034861882 sameAs 2034861882 @default.
• W2034861882 citedByCount "6" @default.
• W2034861882 countsByYear W20348618822015 @default.
• W2034861882 countsByYear W20348618822016 @default.
• W2034861882 countsByYear W20348618822017 @default.
• W2034861882 countsByYear W20348618822022 @default.
• W2034861882 crossrefType "journal-article" @default.
• W2034861882 hasAuthorship W2034861882A5005515378 @default.
• W2034861882 hasAuthorship W2034861882A5022096000 @default.
• W2034861882 hasAuthorship W2034861882A5046542455 @default.
• W2034861882 hasAuthorship W2034861882A5066353072 @default.
• W2034861882 hasAuthorship W2034861882A5068836221 @default.
• W2034861882 hasConcept C146285616 @default.
• W2034861882 hasConcept C14858245 @default.
• W2034861882 hasConcept C153911025 @default.
• W2034861882 hasConcept C167734588 @default.
• W2034861882 hasConcept C169760540 @default.
• W2034861882 hasConcept C178790620 @default.
• W2034861882 hasConcept C185592680 @default.
• W2034861882 hasConcept C201750760 @default.
• W2034861882 hasConcept C2777025900 @default.
• W2034861882 hasConcept C2777093970 @default.
• W2034861882 hasConcept C2778271429 @default.
• W2034861882 hasConcept C2780394083 @default.
• W2034861882 hasConcept C2780672939 @default.
• W2034861882 hasConcept C2780827179 @default.
• W2034861882 hasConcept C2781359195 @default.
• W2034861882 hasConcept C28328180 @default.
• W2034861882 hasConcept C502942594 @default.
• W2034861882 hasConcept C540031477 @default.
• W2034861882 hasConcept C55493867 @default.
• W2034861882 hasConcept C60781801 @default.
• W2034861882 hasConcept C86803240 @default.
• W2034861882 hasConcept C95444343 @default.
• W2034861882 hasConceptScore W2034861882C146285616 @default.
• W2034861882 hasConceptScore W2034861882C14858245 @default.
• W2034861882 hasConceptScore W2034861882C153911025 @default.
• W2034861882 hasConceptScore W2034861882C167734588 @default.
• W2034861882 hasConceptScore W2034861882C169760540 @default.
• W2034861882 hasConceptScore W2034861882C178790620 @default.
• W2034861882 hasConceptScore W2034861882C185592680 @default.
• W2034861882 hasConceptScore W2034861882C201750760 @default.
• W2034861882 hasConceptScore W2034861882C2777025900 @default.
• W2034861882 hasConceptScore W2034861882C2777093970 @default.
• W2034861882 hasConceptScore W2034861882C2778271429 @default.
• W2034861882 hasConceptScore W2034861882C2780394083 @default.
• W2034861882 hasConceptScore W2034861882C2780672939 @default.
• W2034861882 hasConceptScore W2034861882C2780827179 @default.
• W2034861882 hasConceptScore W2034861882C2781359195 @default.
• W2034861882 hasConceptScore W2034861882C28328180 @default.
• W2034861882 hasConceptScore W2034861882C502942594 @default.
• W2034861882 hasConceptScore W2034861882C540031477 @default.
• W2034861882 hasConceptScore W2034861882C55493867 @default.
• W2034861882 hasConceptScore W2034861882C60781801 @default.

• next