FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034861942> ?p ?o ?g. }

• W2034861942 endingPage "1147.e2" @default.
• W2034861942 startingPage "1141" @default.
• W2034861942 abstract "Eicosanoids, important signaling and inflammatory molecules, are present in exhaled breath condensate (EBC) in very low concentrations, requiring highly sensitive analytic methods for their quantification.We sought to assess a vast platform of eicosanoids in different asthma phenotypes, including aspirin-intolerant asthma, by means of a recently developed analytic approach based on mass spectrometry.EBC from 115 adult asthmatic subjects (62 with aspirin intolerance) and 38 healthy control subjects were assessed quantitatively for 19 eicosanoids by using complementary HPLC, gas chromatography-mass spectrometry, or both. Palmitic acid concentrations were used as a marker for dilution of condensate samples.Asthma was characterized by an increase in arachidonate lipoxygenase products and cysteinyl leukotrienes. The COX pathway was also significantly upregulated in asthmatic subjects. Subjects with aspirin-intolerant asthma were distinguished by a sharp increase in the level of prostaglandin D(2) and E(2) metabolites; their 5- and 15-hydroxyeicosateraenoic acid levels were also higher than in aspirin-tolerant subjects. A classical discriminant analysis permitted us to classify correctly 99% of asthmatic subjects within the study population; the specificity of the analysis was 97%. The eicosanoid profiling allowed for 92% correct classification of aspirin-intolerant subjects.The highly sensitive eicosanoid profiling in EBC makes it possible to detect alterations in asthma, especially in its distinct phenotype characterized by hypersensitivity to aspirin and other nonsteroidal anti-inflammatory drugs. This permits us to discriminate asthmatic subjects from healthy subjects, as well as to distinguish the 2 asthma phenotypes based on the presence or absence of aspirin hypersensitivity." @default.
• W2034861942 created "2016-06-24" @default.
• W2034861942 creator A5017061318 @default.
• W2034861942 creator A5056013165 @default.
• W2034861942 creator A5056150470 @default.
• W2034861942 creator A5067910038 @default.
• W2034861942 creator A5070285124 @default.
• W2034861942 creator A5082512213 @default.
• W2034861942 date "2011-05-01" @default.
• W2034861942 modified "2023-10-16" @default.
• W2034861942 title "Targeted eicosanoid lipidomics of exhaled breath condensate provide a distinct pattern in the aspirin-intolerant asthma phenotype" @default.
• W2034861942 cites W1948059877 @default.
• W2034861942 cites W1986702487 @default.
• W2034861942 cites W1989935661 @default.
• W2034861942 cites W2000541190 @default.
• W2034861942 cites W2002122859 @default.
• W2034861942 cites W2007698831 @default.
• W2034861942 cites W2010336522 @default.
• W2034861942 cites W2013999949 @default.
• W2034861942 cites W2016503090 @default.
• W2034861942 cites W2020712150 @default.
• W2034861942 cites W2020767120 @default.
• W2034861942 cites W2024324908 @default.
• W2034861942 cites W2028705982 @default.
• W2034861942 cites W2031343440 @default.
• W2034861942 cites W2031578309 @default.
• W2034861942 cites W2035388693 @default.
• W2034861942 cites W2044880620 @default.
• W2034861942 cites W2047850339 @default.
• W2034861942 cites W2051328865 @default.
• W2034861942 cites W2073850513 @default.
• W2034861942 cites W2074086024 @default.
• W2034861942 cites W2082484551 @default.
• W2034861942 cites W2082728774 @default.
• W2034861942 cites W2085793029 @default.
• W2034861942 cites W2099492946 @default.
• W2034861942 cites W2106557071 @default.
• W2034861942 cites W2117636466 @default.
• W2034861942 cites W2124306546 @default.
• W2034861942 cites W2125306329 @default.
• W2034861942 cites W2131296354 @default.
• W2034861942 cites W2162392918 @default.
• W2034861942 cites W2165396308 @default.
• W2034861942 cites W2166151261 @default.
• W2034861942 cites W2616424562 @default.
• W2034861942 cites W4214563914 @default.
• W2034861942 doi "https://doi.org/10.1016/j.jaci.2010.12.1108" @default.
• W2034861942 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21315430" @default.
• W2034861942 hasPublicationYear "2011" @default.
• W2034861942 type Work @default.
• W2034861942 sameAs 2034861942 @default.
• W2034861942 citedByCount "59" @default.
• W2034861942 countsByYear W20348619422012 @default.
• W2034861942 countsByYear W20348619422013 @default.
• W2034861942 countsByYear W20348619422014 @default.
• W2034861942 countsByYear W20348619422015 @default.
• W2034861942 countsByYear W20348619422016 @default.
• W2034861942 countsByYear W20348619422017 @default.
• W2034861942 countsByYear W20348619422018 @default.
• W2034861942 countsByYear W20348619422019 @default.
• W2034861942 countsByYear W20348619422020 @default.
• W2034861942 countsByYear W20348619422021 @default.
• W2034861942 countsByYear W20348619422022 @default.
• W2034861942 countsByYear W20348619422023 @default.
• W2034861942 crossrefType "journal-article" @default.
• W2034861942 hasAuthorship W2034861942A5017061318 @default.
• W2034861942 hasAuthorship W2034861942A5056013165 @default.
• W2034861942 hasAuthorship W2034861942A5056150470 @default.
• W2034861942 hasAuthorship W2034861942A5067910038 @default.
• W2034861942 hasAuthorship W2034861942A5070285124 @default.
• W2034861942 hasAuthorship W2034861942A5082512213 @default.
• W2034861942 hasBestOaLocation W20348619422 @default.
• W2034861942 hasConcept C126322002 @default.
• W2034861942 hasConcept C181199279 @default.
• W2034861942 hasConcept C185592680 @default.
• W2034861942 hasConcept C203014093 @default.
• W2034861942 hasConcept C2776042228 @default.
• W2034861942 hasConcept C2776352991 @default.
• W2034861942 hasConcept C2776452501 @default.
• W2034861942 hasConcept C2777628954 @default.
• W2034861942 hasConcept C2778078955 @default.
• W2034861942 hasConcept C2780037985 @default.
• W2034861942 hasConcept C2908647359 @default.
• W2034861942 hasConcept C55493867 @default.
• W2034861942 hasConcept C71924100 @default.
• W2034861942 hasConcept C99454951 @default.
• W2034861942 hasConceptScore W2034861942C126322002 @default.
• W2034861942 hasConceptScore W2034861942C181199279 @default.
• W2034861942 hasConceptScore W2034861942C185592680 @default.
• W2034861942 hasConceptScore W2034861942C203014093 @default.
• W2034861942 hasConceptScore W2034861942C2776042228 @default.
• W2034861942 hasConceptScore W2034861942C2776352991 @default.
• W2034861942 hasConceptScore W2034861942C2776452501 @default.
• W2034861942 hasConceptScore W2034861942C2777628954 @default.
• W2034861942 hasConceptScore W2034861942C2778078955 @default.
• W2034861942 hasConceptScore W2034861942C2780037985 @default.
• W2034861942 hasConceptScore W2034861942C2908647359 @default.
• W2034861942 hasConceptScore W2034861942C55493867 @default.

• next