Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034863650> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2034863650 abstract "Maternal endothelial dysfunction and inflammation are associated with hypertensive pregnancy disorders.To investigate maternal endothelial function in normal pregnancy using two different methods and explore their association with markers of inflammatory response.53 women with uncomplicated pregnancies were examined at four-weekly intervals during 22-40weeks gestation. Maternal endothelial function was assessed using flow-mediated vasodilatation (FMD) of brachial artery. FMD was defined as the increase of brachial artery diameter in percent during reactive hyperemia compared to the resting diameter. Circulating EPC were defined as CD45low/CD34+/VEGFR2+ and quantified by flow cytometry. Concentration of the two markers of inflammatory response, i.e. leptin (immunoassay) and highly sensitive CRP (mCRP) (immunoturbidimetric method) were measured in the plasma samples.FMD decreased from 16.3% to 13.4% and concentration of EPC increased from 6.5 to 12.3 per million mononuclear cells during 22-40 weeks. Leptin increased from 18 to 22ng/L and mCRP did not change significantly (p=0.61). Significant associations were observed between FMD and mCRP (p=0.0016), and between FMD and leptin (p=0.0029). There was no significant association between EPC and FMD or between EPC and mCRP.FMD decreases, whereas the concentration of circulating EPC increases with advancing gestation during the second half of pregnancy. However, FMD was associated with biomarkers of inflammation but not with EPC. This suggests that the reduced NO-dependent vasodilatation observed in the third trimester of normal pregnancy is related to maternal inflammatory response. Mechanisms other than effective mobilization of EPC to repair endothelial damage are likely to be responsible for gestational age-associated increase in circulating EPC during pregnancy." @default.
- W2034863650 created "2016-06-24" @default.
- W2034863650 creator A5009213414 @default.
- W2034863650 creator A5019615018 @default.
- W2034863650 creator A5022001201 @default.
- W2034863650 creator A5025300413 @default.
- W2034863650 creator A5031573563 @default.
- W2034863650 creator A5062202535 @default.
- W2034863650 date "2013-04-01" @default.
- W2034863650 modified "2023-09-24" @default.
- W2034863650 title "OP001. A longitudinal study of maternal vascular reactivity, circulating endothelial progenitor cells and inflammatory response during the second half of pregnancy" @default.
- W2034863650 doi "https://doi.org/10.1016/j.preghy.2013.04.017" @default.
- W2034863650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26105848" @default.
- W2034863650 hasPublicationYear "2013" @default.
- W2034863650 type Work @default.
- W2034863650 sameAs 2034863650 @default.
- W2034863650 citedByCount "0" @default.
- W2034863650 crossrefType "journal-article" @default.
- W2034863650 hasAuthorship W2034863650A5009213414 @default.
- W2034863650 hasAuthorship W2034863650A5019615018 @default.
- W2034863650 hasAuthorship W2034863650A5022001201 @default.
- W2034863650 hasAuthorship W2034863650A5025300413 @default.
- W2034863650 hasAuthorship W2034863650A5031573563 @default.
- W2034863650 hasAuthorship W2034863650A5062202535 @default.
- W2034863650 hasConcept C120770815 @default.
- W2034863650 hasConcept C126322002 @default.
- W2034863650 hasConcept C134018914 @default.
- W2034863650 hasConcept C194832188 @default.
- W2034863650 hasConcept C203014093 @default.
- W2034863650 hasConcept C2776914184 @default.
- W2034863650 hasConcept C2777604165 @default.
- W2034863650 hasConcept C2779234561 @default.
- W2034863650 hasConcept C2780613262 @default.
- W2034863650 hasConcept C2780972559 @default.
- W2034863650 hasConcept C46973012 @default.
- W2034863650 hasConcept C511355011 @default.
- W2034863650 hasConcept C54355233 @default.
- W2034863650 hasConcept C553184892 @default.
- W2034863650 hasConcept C71924100 @default.
- W2034863650 hasConcept C84393581 @default.
- W2034863650 hasConcept C86803240 @default.
- W2034863650 hasConceptScore W2034863650C120770815 @default.
- W2034863650 hasConceptScore W2034863650C126322002 @default.
- W2034863650 hasConceptScore W2034863650C134018914 @default.
- W2034863650 hasConceptScore W2034863650C194832188 @default.
- W2034863650 hasConceptScore W2034863650C203014093 @default.
- W2034863650 hasConceptScore W2034863650C2776914184 @default.
- W2034863650 hasConceptScore W2034863650C2777604165 @default.
- W2034863650 hasConceptScore W2034863650C2779234561 @default.
- W2034863650 hasConceptScore W2034863650C2780613262 @default.
- W2034863650 hasConceptScore W2034863650C2780972559 @default.
- W2034863650 hasConceptScore W2034863650C46973012 @default.
- W2034863650 hasConceptScore W2034863650C511355011 @default.
- W2034863650 hasConceptScore W2034863650C54355233 @default.
- W2034863650 hasConceptScore W2034863650C553184892 @default.
- W2034863650 hasConceptScore W2034863650C71924100 @default.
- W2034863650 hasConceptScore W2034863650C84393581 @default.
- W2034863650 hasConceptScore W2034863650C86803240 @default.
- W2034863650 hasLocation W20348636501 @default.
- W2034863650 hasLocation W20348636502 @default.
- W2034863650 hasOpenAccess W2034863650 @default.
- W2034863650 hasPrimaryLocation W20348636501 @default.
- W2034863650 hasRelatedWork W1575395016 @default.
- W2034863650 hasRelatedWork W1731174171 @default.
- W2034863650 hasRelatedWork W1950215363 @default.
- W2034863650 hasRelatedWork W2028430421 @default.
- W2034863650 hasRelatedWork W2089630523 @default.
- W2034863650 hasRelatedWork W2108371395 @default.
- W2034863650 hasRelatedWork W2160243153 @default.
- W2034863650 hasRelatedWork W2230506993 @default.
- W2034863650 hasRelatedWork W2334994929 @default.
- W2034863650 hasRelatedWork W2354934241 @default.
- W2034863650 hasRelatedWork W2356423677 @default.
- W2034863650 hasRelatedWork W2359709031 @default.
- W2034863650 hasRelatedWork W2383019429 @default.
- W2034863650 hasRelatedWork W2401983608 @default.
- W2034863650 hasRelatedWork W2414745512 @default.
- W2034863650 hasRelatedWork W2605633598 @default.
- W2034863650 hasRelatedWork W2624660959 @default.
- W2034863650 hasRelatedWork W2766513643 @default.
- W2034863650 hasRelatedWork W2911800489 @default.
- W2034863650 hasRelatedWork W3111965797 @default.
- W2034863650 isParatext "false" @default.
- W2034863650 isRetracted "false" @default.
- W2034863650 magId "2034863650" @default.
- W2034863650 workType "article" @default.