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- W2034865595 abstract "To assess the level of occlusion and arterial distribution of a new calibrated bioresorbable hydrogel microsphere after renal arterial embolization. Bioresorbable hydrogel microspheres (BRMS) were prepared from natural polymers using an inverse emulsion method. 3 left kidneys from 3 adult rabbits (white, New Zealand) were embolized with 100–300 μm BRMS with a mean diameter of 250 ± 25 μm until total occlusion was achieved, while 3 right kidneys were embolized with Embospheres® (EBMS, BioSphere Medical, Inc. MA) in the same size range and to the same end point for comparison. After euthanasia of the rabbits, the kidneys were removed and fixed in 10% formalin. Coronal histological sections were obtained from each kidney and stained with hematoxylin and eosin (H&E) for histological analyzing. The number of microspheres and the size of vessels were measured and the arterial level of occlusion (interlobar, arcuate, or interlobular arteries) in the kidney was studied. During the embolization procedure, the injection of BRMS through microcatheter was easy and no clogging or aggregation was observed. Both types of microspheres were found in all three arterial locations in the kidney. The locations of BRMS and EBMS within the vasculature were slightly different with BRMS blocking slightly more proximally than EBMS (P <0.001). The percentage of the microspheres found in the interlobar artery, the arcuate artery, and the interlobular artery were 16.3%, 31.3% and 52.4% for BRMS, respectively, whereas they were 15.8%, 34.1%, and 50.1% for EBMS, respectively. Two hundred fifty vessels were measured to assess the mean diameter of the vessels occluded. The mean diameter of the occluded vessels was 197 ± 11 μm for BRMS and 158 ± 11 μm for EBMS (P <0.001), respectively. The mean diameter of the occluded vessels for BRMS is close to the mean diameter of the sieve aperture size 200 μm, i.e. the calibrated size. BRMS can embolize the blood vessel at the desired level. Compared to EBMS with respect to the repartition of microspheres in the arteries, BRMS occluded a little more proximal in the artery, but the difference is not significant." @default.
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- W2034865595 date "2011-03-01" @default.
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- W2034865595 title "Abstract No. 56: Level of occlusion and arterial distribution of calibrated bioresorbable hydrogel microspheres in a rabbit kidney model" @default.
- W2034865595 doi "https://doi.org/10.1016/j.jvir.2011.01.062" @default.
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