FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034867543> ?p ?o ?g. }

• W2034867543 endingPage "19" @default.
• W2034867543 startingPage "19" @default.
• W2034867543 abstract "Impact of ghrelin on vitreous cytokine levels in an experimental uveitis model Burak Turgut,1 Fatih Cem Gül,1 Ferda Dağli,2 Nevin Ilhan,3 Metin Özgen41Department of Ophthalmology, School of Medicine, Firat University, Elazig, 2Department of Pathology, School of Medicine, İnönü University, Malatya, 3Department of Biochemistry, School of Medicine, Firat University, Elazig, 4Department of Rheumatology, School of Medicine, İnönü University, Malatya, TurkeyBackground: The purpose of this study was to investigate the effect of intraperitoneal ghrelin on vitreous levels of interleukin (IL)-1, IL-6, and tumor necrosis factor-alpha (TNF-α) and to compare its effects with those of intraperitoneal infliximab in an experimental uveitis model.Methods: Twenty-four male rats were assigned to four groups of six rats in each. All the rats, except for those in group 1 (controls), were injected intravitreally with concanavalin A to induce experimental uveitis. Rats in group 2 (sham) were not given any treatment after uveitis was induced. Rats in group 3 were given intraperitoneal infliximab 0.5 mg/100 mL on days 0, 1, 3, 5, and 7 following induction of uveitis on day 14 of the study. Rats in group 4 were given intraperitoneal ghrelin 10 ng/kg/day for 7 days following induction of uveitis. On day 21 of the study, enucleated globes were subjected to histopathologic examination. Vitreous levels of IL-1, IL-6, and TNF-α were measured by enzyme-linked immunosorbent assay.Results: Vitreous levels of IL-1, IL-6, and TNF-α were significantly increased in the sham group relative to the control group (P < 0.05), but showed a significant decrease in the group treated with infliximab (P < 0.05). Cytokine levels also decreased in the ghrelin-treated group, but the decrease was not statistically significant (P > 0.05).Conclusion: Ghrelin failed to decrease the IL-1, IL-6, and TNF-α levels that play a critical role in the pathogenesis of uveitis.Keywords: uveitis, tumor necrosis factor-alpha, interleukin-1, interleukin-6, infliximab, ghrelin" @default.
• W2034867543 created "2016-06-24" @default.
• W2034867543 creator A5039672518 @default.
• W2034867543 creator A5048631577 @default.
• W2034867543 creator A5070539251 @default.
• W2034867543 creator A5071564465 @default.
• W2034867543 creator A5088478457 @default.
• W2034867543 date "2013-01-01" @default.
• W2034867543 modified "2023-10-13" @default.
• W2034867543 title "Impact of ghrelin on vitreous cytokine levels in an experimental uveitis model" @default.
• W2034867543 cites W152991990 @default.
• W2034867543 cites W1555027538 @default.
• W2034867543 cites W1637971961 @default.
• W2034867543 cites W174750716 @default.
• W2034867543 cites W1912011094 @default.
• W2034867543 cites W1917311330 @default.
• W2034867543 cites W1963815610 @default.
• W2034867543 cites W1972882423 @default.
• W2034867543 cites W1981125406 @default.
• W2034867543 cites W1986168431 @default.
• W2034867543 cites W1999244000 @default.
• W2034867543 cites W2021310874 @default.
• W2034867543 cites W2033598785 @default.
• W2034867543 cites W2035596800 @default.
• W2034867543 cites W2050960070 @default.
• W2034867543 cites W2051334171 @default.
• W2034867543 cites W2052692391 @default.
• W2034867543 cites W2055941828 @default.
• W2034867543 cites W2069302715 @default.
• W2034867543 cites W2073308867 @default.
• W2034867543 cites W2077485150 @default.
• W2034867543 cites W2082980887 @default.
• W2034867543 cites W2087432719 @default.
• W2034867543 cites W2089504365 @default.
• W2034867543 cites W2091792221 @default.
• W2034867543 cites W2102346999 @default.
• W2034867543 cites W2110766030 @default.
• W2034867543 cites W2114081005 @default.
• W2034867543 cites W2119300545 @default.
• W2034867543 cites W2132043544 @default.
• W2034867543 cites W2139789471 @default.
• W2034867543 cites W2147171610 @default.
• W2034867543 cites W2151472458 @default.
• W2034867543 cites W2158286914 @default.
• W2034867543 cites W2161446589 @default.
• W2034867543 cites W2163865122 @default.
• W2034867543 cites W2166776334 @default.
• W2034867543 cites W2261376713 @default.
• W2034867543 cites W2274031715 @default.
• W2034867543 cites W2439905045 @default.
• W2034867543 cites W71051318 @default.
• W2034867543 cites W1992936149 @default.
• W2034867543 cites W204903678 @default.
• W2034867543 doi "https://doi.org/10.2147/dddt.s39453" @default.
• W2034867543 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3546756" @default.
• W2034867543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23341733" @default.
• W2034867543 hasPublicationYear "2013" @default.
• W2034867543 type Work @default.
• W2034867543 sameAs 2034867543 @default.
• W2034867543 citedByCount "8" @default.
• W2034867543 countsByYear W20348675432014 @default.
• W2034867543 countsByYear W20348675432015 @default.
• W2034867543 countsByYear W20348675432016 @default.
• W2034867543 countsByYear W20348675432017 @default.
• W2034867543 countsByYear W20348675432018 @default.
• W2034867543 countsByYear W20348675432021 @default.
• W2034867543 crossrefType "journal-article" @default.
• W2034867543 hasAuthorship W2034867543A5039672518 @default.
• W2034867543 hasAuthorship W2034867543A5048631577 @default.
• W2034867543 hasAuthorship W2034867543A5070539251 @default.
• W2034867543 hasAuthorship W2034867543A5071564465 @default.
• W2034867543 hasAuthorship W2034867543A5088478457 @default.
• W2034867543 hasBestOaLocation W20348675431 @default.
• W2034867543 hasConcept C118487528 @default.
• W2034867543 hasConcept C126322002 @default.
• W2034867543 hasConcept C17991360 @default.
• W2034867543 hasConcept C2776194053 @default.
• W2034867543 hasConcept C2778690821 @default.
• W2034867543 hasConcept C2779357093 @default.
• W2034867543 hasConcept C2780159080 @default.
• W2034867543 hasConcept C71315377 @default.
• W2034867543 hasConcept C71924100 @default.
• W2034867543 hasConcept C74172505 @default.
• W2034867543 hasConceptScore W2034867543C118487528 @default.
• W2034867543 hasConceptScore W2034867543C126322002 @default.
• W2034867543 hasConceptScore W2034867543C17991360 @default.
• W2034867543 hasConceptScore W2034867543C2776194053 @default.
• W2034867543 hasConceptScore W2034867543C2778690821 @default.
• W2034867543 hasConceptScore W2034867543C2779357093 @default.
• W2034867543 hasConceptScore W2034867543C2780159080 @default.
• W2034867543 hasConceptScore W2034867543C71315377 @default.
• W2034867543 hasConceptScore W2034867543C71924100 @default.
• W2034867543 hasConceptScore W2034867543C74172505 @default.
• W2034867543 hasLocation W20348675431 @default.
• W2034867543 hasLocation W20348675432 @default.
• W2034867543 hasLocation W20348675433 @default.
• W2034867543 hasLocation W20348675434 @default.
• W2034867543 hasLocation W20348675435 @default.

• next