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• W2034871646 abstract "ABSTRACT As nonenveloped viruses, the aquareoviruses and orthoreoviruses are unusual in their ability to induce cell-cell fusion and syncytium formation. While an extraordinary family of fusion-associated small transmembrane (FAST) proteins is responsible for orthoreovirus syncytiogenesis, the basis for aquareovirus-induced syncytiogenesis is unknown. We now report that the S7 genome segment of an Atlantic salmon reovirus is polycistronic and uses a noncanonical CUG translation start codon to produce a 22-kDa integral membrane protein responsible for syncytiogenesis. The aquareovirus p22 protein represents a fourth distinct member of the FAST family with a unique repertoire and arrangement of structural motifs." @default.
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• W2034871646 date "2009-06-01" @default.
• W2034871646 modified "2023-09-26" @default.
• W2034871646 title "Aquareovirus Effects Syncytiogenesis by Using a Novel Member of the FAST Protein Family Translated from a Noncanonical Translation Start Site" @default.
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• W2034871646 doi "https://doi.org/10.1128/jvi.00171-09" @default.
• W2034871646 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2681948" @default.
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