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• W2034871809 startingPage "11596" @default.
• W2034871809 abstract "African trypanosomes compartmentalize glycolysis in a microbody, the glycosome. When growing in the mammalian bloodstream, trypanosomes contain only a rudimentary mitochondrion, and the first seven glycolytic enzymes, including phosphoglycerate kinase, are located in the glycosome. Procyclic trypanosomes, growing in the gut of tsetse flies, possess a fully developed mitochondrion that is active in oxidative phosphorylation. The first six glycolytic enzymes are still glycosomal, but phosphoglycerate kinase is now found in the cytosol. We demonstrate here that bloodstream trypanosomes are killed by expression of cytosolic phosphoglycerate kinase. The toxicity depends on both enzyme activity and cytosolic location. One possible explanation is that cytosolic phosphoglycerate kinase creates an ATP-generating shunt in the cytosol, thus preventing full ATP regeneration in the glycosome and ultimately inhibiting the first, ATP-consuming, steps of glycolysis." @default.
• W2034871809 created "2016-06-24" @default.
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• W2034871809 date "1998-09-29" @default.
• W2034871809 modified "2023-10-02" @default.
• W2034871809 title "Compartmentation of phosphoglycerate kinase in <i>Trypanosoma brucei</i> plays a critical role in parasite energy metabolism" @default.
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• W2034871809 doi "https://doi.org/10.1073/pnas.95.20.11596" @default.
• W2034871809 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/21686" @default.
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