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- W2034872664 abstract "Summary: The cardiac electrophysiological effects of metoprolol were studied in ten patients (pts) aged 22–51 years undergoing intracardiac stimulation studies for paroxysmal palpitations. The following measurements were made: (1) basic sinus cycle length (SCL); (2) sinus node recovery time (SRT) following overdrive pacing; (3) atrio-His (A-H) and His-ventricular (H-V) conduction intervals during regular atrial pacing; (4) effective refractory periods of the atria (AERP), A-V node (AVERP) and ventricular myocardium (VERP); and (5) A-V nodal functional refractory period (AVFRP). All measurements were repeated 10–20 min after a slow bolus intravenous injection of metoprolol (0.2 mg/kg body weight). Results were analyzed by the Wilcoxon Signed Rank test. Highly significant increases in: SRT (932±166 to 1107±225 ms, p<0.001) and A-H (72±14 to 103± 14 ms, p<0.001) were observed. There were also small increases of lesser significance in SCL (794± 160 to 898±190 ms, p<0.01), AVERP (308±46 to 341±66 ms, p<0.02), and AVFRP (376±43 to 416±59 ms, p<0.01). Metoprolol did not affect the H-V interval, the AERP, or the VERP. These results are similar to those of other beta blockers." @default.
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- W2034872664 date "1982-05-01" @default.
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- W2034872664 title "The acute electrophysiological effects of intravenous metoprolol" @default.
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- W2034872664 doi "https://doi.org/10.1002/clc.4960050503" @default.
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