FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034872788> ?p ?o ?g. }

• W2034872788 endingPage "G781" @default.
• W2034872788 startingPage "G772" @default.
• W2034872788 abstract "In humans and cats, muscle from the lower esophageal sphincter (LES) circular region exhibits greater spontaneous tone than LES sling muscle, whereas the sling muscle is much more responsive to cholinergic stimulation. Despite physiological and pharmacological evidence for the presence of L-type Ca 2+ channel current ( I Ca,L ) activity in LES circular muscle, the identity of this channel has not been demonstrated biochemically or electrophysiologically fingerprinted. Furthermore, there is no information on the channel's presence and role in the sling region of the LES. We hypothesized that regional differences in the expression of I Ca,L between LES circular and sling muscles, if present, could contribute to the functional asymmetry observed within the LES. I Ca,L expression was compared between circular and sling regions of the LES by Western blot analysis. The patch-clamp technique was used to study I Ca,L . Muscle strip studies assessed I Ca,L contribution to contractile activity. We found both protein expression of I Ca,L and I Ca,L density to be greater in LES circular muscle than sling muscle. I Ca,L voltage- and time-dependent activation and inactivation curves were similar in cells from both regions. I Ca,L blockade with nifedipine inhibited spontaneous tone and ACh-induced contractions only in circular muscle but was able to abolish depolarization (KCl)-induced contractions in both sling and circular muscles. In contrast, La 3+ inhibited tone and ACh-induced contractions in muscles from both regions. Therefore, regional myogenic differences in I Ca,L expression within the LES circular and sling muscle exist and provide one explanation for the differential contribution of sling and circular muscle to LES contractility." @default.
• W2034872788 created "2016-06-24" @default.
• W2034872788 creator A5019687913 @default.
• W2034872788 creator A5060106697 @default.
• W2034872788 creator A5064292555 @default.
• W2034872788 creator A5087070321 @default.
• W2034872788 date "2004-10-01" @default.
• W2034872788 modified "2023-09-25" @default.
• W2034872788 title "Regional differences in L-type Ca²⁺channel expression in feline lower esophageal sphincter" @default.
• W2034872788 cites W1428098757 @default.
• W2034872788 cites W1744363196 @default.
• W2034872788 cites W1787576839 @default.
• W2034872788 cites W181032955 @default.
• W2034872788 cites W1899877571 @default.
• W2034872788 cites W1983948790 @default.
• W2034872788 cites W2011351237 @default.
• W2034872788 cites W2021858120 @default.
• W2034872788 cites W2023572817 @default.
• W2034872788 cites W2035460326 @default.
• W2034872788 cites W2043606809 @default.
• W2034872788 cites W2052055142 @default.
• W2034872788 cites W2059095114 @default.
• W2034872788 cites W2061094990 @default.
• W2034872788 cites W2082477343 @default.
• W2034872788 cites W2089742414 @default.
• W2034872788 cites W2107409734 @default.
• W2034872788 cites W2126434737 @default.
• W2034872788 cites W2127734534 @default.
• W2034872788 cites W2132331561 @default.
• W2034872788 cites W2137393041 @default.
• W2034872788 cites W2150504986 @default.
• W2034872788 cites W2152416486 @default.
• W2034872788 cites W2152869269 @default.
• W2034872788 cites W2160043121 @default.
• W2034872788 cites W2163392128 @default.
• W2034872788 cites W2235567064 @default.
• W2034872788 cites W2270307319 @default.
• W2034872788 cites W2270898887 @default.
• W2034872788 cites W2282198984 @default.
• W2034872788 cites W2291043738 @default.
• W2034872788 cites W2291389011 @default.
• W2034872788 cites W2401694195 @default.
• W2034872788 cites W2409872135 @default.
• W2034872788 cites W2462586261 @default.
• W2034872788 cites W52321004 @default.
• W2034872788 doi "https://doi.org/10.1152/ajpgi.00102.2004" @default.
• W2034872788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15178551" @default.
• W2034872788 hasPublicationYear "2004" @default.
• W2034872788 type Work @default.
• W2034872788 sameAs 2034872788 @default.
• W2034872788 citedByCount "21" @default.
• W2034872788 countsByYear W20348727882012 @default.
• W2034872788 countsByYear W20348727882016 @default.
• W2034872788 countsByYear W20348727882017 @default.
• W2034872788 countsByYear W20348727882020 @default.
• W2034872788 countsByYear W20348727882021 @default.
• W2034872788 countsByYear W20348727882023 @default.
• W2034872788 crossrefType "journal-article" @default.
• W2034872788 hasAuthorship W2034872788A5019687913 @default.
• W2034872788 hasAuthorship W2034872788A5060106697 @default.
• W2034872788 hasAuthorship W2034872788A5064292555 @default.
• W2034872788 hasAuthorship W2034872788A5087070321 @default.
• W2034872788 hasConcept C105702510 @default.
• W2034872788 hasConcept C126322002 @default.
• W2034872788 hasConcept C134018914 @default.
• W2034872788 hasConcept C141071460 @default.
• W2034872788 hasConcept C163415756 @default.
• W2034872788 hasConcept C178103971 @default.
• W2034872788 hasConcept C185592680 @default.
• W2034872788 hasConcept C22885893 @default.
• W2034872788 hasConcept C24998067 @default.
• W2034872788 hasConcept C2776050358 @default.
• W2034872788 hasConcept C2779066535 @default.
• W2034872788 hasConcept C2780877482 @default.
• W2034872788 hasConcept C2991787047 @default.
• W2034872788 hasConcept C2992686903 @default.
• W2034872788 hasConcept C4141045 @default.
• W2034872788 hasConcept C519063684 @default.
• W2034872788 hasConcept C71924100 @default.
• W2034872788 hasConcept C86803240 @default.
• W2034872788 hasConceptScore W2034872788C105702510 @default.
• W2034872788 hasConceptScore W2034872788C126322002 @default.
• W2034872788 hasConceptScore W2034872788C134018914 @default.
• W2034872788 hasConceptScore W2034872788C141071460 @default.
• W2034872788 hasConceptScore W2034872788C163415756 @default.
• W2034872788 hasConceptScore W2034872788C178103971 @default.
• W2034872788 hasConceptScore W2034872788C185592680 @default.
• W2034872788 hasConceptScore W2034872788C22885893 @default.
• W2034872788 hasConceptScore W2034872788C24998067 @default.
• W2034872788 hasConceptScore W2034872788C2776050358 @default.
• W2034872788 hasConceptScore W2034872788C2779066535 @default.
• W2034872788 hasConceptScore W2034872788C2780877482 @default.
• W2034872788 hasConceptScore W2034872788C2991787047 @default.
• W2034872788 hasConceptScore W2034872788C2992686903 @default.
• W2034872788 hasConceptScore W2034872788C4141045 @default.
• W2034872788 hasConceptScore W2034872788C519063684 @default.
• W2034872788 hasConceptScore W2034872788C71924100 @default.
• W2034872788 hasConceptScore W2034872788C86803240 @default.

• next