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• W2034874517 abstract "<i>Objective:</i> Inflammatory conditions contribute to increased expression of various activity markers in platelets and endothelial cells, leading to atherosclerotic changes in the vascular wall. The objective of this study was to investigate possible protective effects of 1α,25-dihydroxyvitamin D₃ in an endothelial cell model. <i>Methods:</i> After a 24-hour incubation with 1α,25-dihydroxyvitamin D₃, human umbilical vein endothelial cells were stimulated with lipopolysaccharide (LPS) and incubated in direct contact with platelets. The expression of CD40L and CD62P in platelets, the expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 (VCAM-1), the urokinase receptor uPAR and membrane type 1 matrix metalloproteinase (MT1-MMP) in endothelial cells and endothelial cell reactive oxygen species generation were measured by flow cytometry. Endothelial nitric oxide synthase was analyzed by Western blot. <i>Results:</i> The increased expression of VCAM-1 and MT1-MMP in endothelial cells by proinflammatory stimulation with LPS and by direct contact with activated platelets was significantly reduced through preincubation with 1α,25-dihydroxyvitamin D₃. Platelets in direct contact with preincubated endothelial cells showed significantly reduced CD62P expression when compared to platelets incubated with untreated endothelial cells. <i>Conclusions:</i> 1α,25-Dihydroxyvitamin D₃ attenuates platelet activation and the expression of VCAM-1 and MT1-MMP in human endothelial cells and could have early therapeutic relevance in atherosclerotic diseases." @default.
• W2034874517 created "2016-06-24" @default.
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• W2034874517 date "2011-01-01" @default.
• W2034874517 modified "2023-10-16" @default.
• W2034874517 title "1α,25-Dihydroxyvitamin D₃ Attenuates Platelet Activation and the Expression of VCAM-1 and MT1-MMP in Human Endothelial Cells" @default.
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• W2034874517 cites W1993754429 @default.
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• W2034874517 cites W2028197171 @default.
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• W2034874517 cites W2038249373 @default.
• W2034874517 cites W2039881470 @default.
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• W2034874517 cites W2045480275 @default.
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• W2034874517 doi "https://doi.org/10.1159/000327547" @default.
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