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- W2034874949 abstract "The plasma potassium responses to the aldosterone antagonists prorenoate K (10 mg/day and 40 mg/day) and spironolactone (25 mg/day and 100 mg/day) were compared following treatment for 11 days in combination with the diuretic metolazone (2.5 mg/day) in a double-blind crossover study in twelve healthy men. The best estimate of the potency of prorenoate K relative to spironolactone in attenuating metolazone induced hypokalaemia was 5.6 with 95% confidence limits 2.4-35.2. The method employed allowed a statistically valid quantitative comparison of the potassium sparing properties of the mineralocorticoid antagonists after repeated doses and may be useful in the preclinical evaluation of these drugs." @default.
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- W2034874949 date "1984-08-01" @default.
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- W2034874949 title "Relative potency of prorenoate potassium and spironolactone in attenuating diuretic induced hypokalaemia." @default.
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- W2034874949 doi "https://doi.org/10.1111/j.1365-2125.1984.tb02449.x" @default.
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