Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034876620> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2034876620 endingPage "S48" @default.
- W2034876620 startingPage "S48" @default.
- W2034876620 abstract "167 Chemokines function in the recruitment as well as in the activation of leukocytes. Recent studies in animal models suggest that they play an important role in acute and chronic allograft rejection. However, little is reported on the expression or function of chemokines in human allografts. In this study we have examined the expression of RANTES (Ran), MCP-1, Mig, IP-10, SDF-1, lymphotactin (Lt), and eotaxin mRNA in human cardiac allograft biopsies by semiquantitative RT-PCR. The expression of the chemokine receptors CCR1, CCR3, CCR5 and CXCR3 were examined in separate biopsies by immunohistochemistry. Biopsies taken at the same time as the study biopsies were examined for the clinicopathologic diagnosis of rejection using the ISHLT scoring system. A total of 44 biopsies (n=44 patients) were examined by RT-PCR. Rejection grade 1A was found in 6 biopsies and grade 2 in 5 biopsies. No rejection was found in 33 biopsies. The expression of chemokines are summarized in the (Table) as the percentage of biopsies expressing the chemokine.TableA total of 27 biopsies were examined by immunohistochemistry. CCR3 was found on resident cells and on infiltrating mononuclear cells in most biopsies, without any association with rejection. CCR5 was found in 41 % of biopsies on occasionally infiltrating leukocytes, and was not associated with the histological diagnoses. In contrast, the expression of CXCR3 and CCR1 was associated with the presence of CD3+ T cell infiltrates (p<0.05). Furthermore, in the absence of CXCR3- or CCR1-expressing infiltrates there was no evidence of rejection. In addition, in most biopsies with CD3+ T cell infiltrates and rejection CXCR3- and CCR1-expressing cells were present. Thus, the expression of eotaxin, SDF-1 and lymphotactin, as well as of CCR3 is common in human cardiac allograft biopsies and is not associated with the clinicopathologic diagnosis. In contrast, RANTES and IP-10 as well as their receptors CCR1 and CXCR3 may be associated with acute rejection. Since chronic rejection is associated with MCP-1 and Mig expression, we speculate that the lack of expression of MCP-1 and Mig in low-grade rejection may be of functional significance for long term outcome." @default.
- W2034876620 created "2016-06-24" @default.
- W2034876620 creator A5026740203 @default.
- W2034876620 creator A5038274554 @default.
- W2034876620 creator A5047555474 @default.
- W2034876620 creator A5070980712 @default.
- W2034876620 creator A5074223365 @default.
- W2034876620 creator A5081164176 @default.
- W2034876620 date "1999-04-01" @default.
- W2034876620 modified "2023-09-23" @default.
- W2034876620 title "EXPRESSION OF CHEMOKINES AND CHEMOKINE RECEPTORS IN HUMAN CARDIAC ALLOGRAFTS: ASSOCIATION WITH CD3+ T CELL INTILTRATES AND REJECTION" @default.
- W2034876620 doi "https://doi.org/10.1097/00007890-199904150-00195" @default.
- W2034876620 hasPublicationYear "1999" @default.
- W2034876620 type Work @default.
- W2034876620 sameAs 2034876620 @default.
- W2034876620 citedByCount "0" @default.
- W2034876620 crossrefType "journal-article" @default.
- W2034876620 hasAuthorship W2034876620A5026740203 @default.
- W2034876620 hasAuthorship W2034876620A5038274554 @default.
- W2034876620 hasAuthorship W2034876620A5047555474 @default.
- W2034876620 hasAuthorship W2034876620A5070980712 @default.
- W2034876620 hasAuthorship W2034876620A5074223365 @default.
- W2034876620 hasAuthorship W2034876620A5081164176 @default.
- W2034876620 hasBestOaLocation W20348766201 @default.
- W2034876620 hasConcept C114684123 @default.
- W2034876620 hasConcept C12823836 @default.
- W2034876620 hasConcept C128879288 @default.
- W2034876620 hasConcept C129013479 @default.
- W2034876620 hasConcept C13373296 @default.
- W2034876620 hasConcept C1423137 @default.
- W2034876620 hasConcept C142724271 @default.
- W2034876620 hasConcept C167672396 @default.
- W2034876620 hasConcept C203014093 @default.
- W2034876620 hasConcept C204232928 @default.
- W2034876620 hasConcept C25532541 @default.
- W2034876620 hasConcept C2775934546 @default.
- W2034876620 hasConcept C29146819 @default.
- W2034876620 hasConcept C71924100 @default.
- W2034876620 hasConcept C8891405 @default.
- W2034876620 hasConcept C94205230 @default.
- W2034876620 hasConceptScore W2034876620C114684123 @default.
- W2034876620 hasConceptScore W2034876620C12823836 @default.
- W2034876620 hasConceptScore W2034876620C128879288 @default.
- W2034876620 hasConceptScore W2034876620C129013479 @default.
- W2034876620 hasConceptScore W2034876620C13373296 @default.
- W2034876620 hasConceptScore W2034876620C1423137 @default.
- W2034876620 hasConceptScore W2034876620C142724271 @default.
- W2034876620 hasConceptScore W2034876620C167672396 @default.
- W2034876620 hasConceptScore W2034876620C203014093 @default.
- W2034876620 hasConceptScore W2034876620C204232928 @default.
- W2034876620 hasConceptScore W2034876620C25532541 @default.
- W2034876620 hasConceptScore W2034876620C2775934546 @default.
- W2034876620 hasConceptScore W2034876620C29146819 @default.
- W2034876620 hasConceptScore W2034876620C71924100 @default.
- W2034876620 hasConceptScore W2034876620C8891405 @default.
- W2034876620 hasConceptScore W2034876620C94205230 @default.
- W2034876620 hasIssue "7" @default.
- W2034876620 hasLocation W20348766201 @default.
- W2034876620 hasOpenAccess W2034876620 @default.
- W2034876620 hasPrimaryLocation W20348766201 @default.
- W2034876620 hasRelatedWork W1966929553 @default.
- W2034876620 hasRelatedWork W1974171294 @default.
- W2034876620 hasRelatedWork W1993565072 @default.
- W2034876620 hasRelatedWork W2034876620 @default.
- W2034876620 hasRelatedWork W2044983494 @default.
- W2034876620 hasRelatedWork W2130892977 @default.
- W2034876620 hasRelatedWork W2155705367 @default.
- W2034876620 hasRelatedWork W3101685330 @default.
- W2034876620 hasRelatedWork W3154902925 @default.
- W2034876620 hasRelatedWork W5755322 @default.
- W2034876620 hasVolume "67" @default.
- W2034876620 isParatext "false" @default.
- W2034876620 isRetracted "false" @default.
- W2034876620 magId "2034876620" @default.
- W2034876620 workType "article" @default.