Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034880050> ?p ?o ?g. }
- W2034880050 endingPage "315" @default.
- W2034880050 startingPage "302" @default.
- W2034880050 abstract "The action of ATP and its analogs as well as the effects of alkali ions were studied in their action on the ouabain receptor. One single ouabain receptor with a dissociation constant (KD) of 13 nM was found in the presence of (Mg2+ + Pi) and (Na+ + Mg2+ + ATP). pH changes below pH 7.4 did not affect the ouabain receptor. Ouabain binding required Mg2+, where a curved line in the Scatchard plot appeared. The affinity of the receptor for ouabain was decreased by K+ and its congeners, by Na+ in the presence of (Mg2+ + Pi), and by ATP analogs (ADP-C-P, ATP-OCH3). Ca2+ antagonized the action of K+ on ouabain binding. It was concluded that the ouabain receptor exists in a low affinity (Rα) and a high affinity conformational state (Rβ). The equilibrium between both states is influenced by ligands of (Na+ + K+)-ATPase. With 3 mM Mg2+ a mixture between both conformational states is assumed to exist (curved line in the Scatchard plot)." @default.
- W2034880050 created "2016-06-24" @default.
- W2034880050 creator A5014401529 @default.
- W2034880050 creator A5028685517 @default.
- W2034880050 date "1973-12-01" @default.
- W2034880050 modified "2023-09-27" @default.
- W2034880050 title "Ouabain receptor interactions in (Na+ + K+)-ATPase preparations. II. Effect of cations and nucleotides on rate constants and dissociation constants" @default.
- W2034880050 cites W14247249 @default.
- W2034880050 cites W1480115832 @default.
- W2034880050 cites W1508939788 @default.
- W2034880050 cites W1536191645 @default.
- W2034880050 cites W1563358922 @default.
- W2034880050 cites W1570489146 @default.
- W2034880050 cites W1587174601 @default.
- W2034880050 cites W1590045255 @default.
- W2034880050 cites W1775749144 @default.
- W2034880050 cites W1960643350 @default.
- W2034880050 cites W1979845674 @default.
- W2034880050 cites W1980127993 @default.
- W2034880050 cites W1980142140 @default.
- W2034880050 cites W1981139209 @default.
- W2034880050 cites W1983649348 @default.
- W2034880050 cites W1986476011 @default.
- W2034880050 cites W1997736698 @default.
- W2034880050 cites W2001264161 @default.
- W2034880050 cites W2004681091 @default.
- W2034880050 cites W2004810229 @default.
- W2034880050 cites W2012249836 @default.
- W2034880050 cites W2012981999 @default.
- W2034880050 cites W2014655613 @default.
- W2034880050 cites W2025674250 @default.
- W2034880050 cites W2026391301 @default.
- W2034880050 cites W2029467036 @default.
- W2034880050 cites W2042329551 @default.
- W2034880050 cites W2044616155 @default.
- W2034880050 cites W2046908885 @default.
- W2034880050 cites W2046955956 @default.
- W2034880050 cites W2067667926 @default.
- W2034880050 cites W2075271837 @default.
- W2034880050 cites W2076932131 @default.
- W2034880050 cites W2084530235 @default.
- W2034880050 cites W2088745100 @default.
- W2034880050 cites W2095137948 @default.
- W2034880050 cites W2097511061 @default.
- W2034880050 cites W2103822775 @default.
- W2034880050 cites W2118002848 @default.
- W2034880050 cites W2120469743 @default.
- W2034880050 cites W2149213512 @default.
- W2034880050 cites W2150357991 @default.
- W2034880050 cites W2205753780 @default.
- W2034880050 cites W3165208394 @default.
- W2034880050 doi "https://doi.org/10.1016/0005-2736(73)90235-6" @default.
- W2034880050 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4272500" @default.
- W2034880050 hasPublicationYear "1973" @default.
- W2034880050 type Work @default.
- W2034880050 sameAs 2034880050 @default.
- W2034880050 citedByCount "78" @default.
- W2034880050 crossrefType "journal-article" @default.
- W2034880050 hasAuthorship W2034880050A5014401529 @default.
- W2034880050 hasAuthorship W2034880050A5028685517 @default.
- W2034880050 hasConcept C102931765 @default.
- W2034880050 hasConcept C104317684 @default.
- W2034880050 hasConcept C12554922 @default.
- W2034880050 hasConcept C170493617 @default.
- W2034880050 hasConcept C178790620 @default.
- W2034880050 hasConcept C185592680 @default.
- W2034880050 hasConcept C2777339483 @default.
- W2034880050 hasConcept C2779133857 @default.
- W2034880050 hasConcept C512185932 @default.
- W2034880050 hasConcept C537181965 @default.
- W2034880050 hasConcept C55493867 @default.
- W2034880050 hasConcept C71240020 @default.
- W2034880050 hasConcept C74998103 @default.
- W2034880050 hasConcept C86803240 @default.
- W2034880050 hasConceptScore W2034880050C102931765 @default.
- W2034880050 hasConceptScore W2034880050C104317684 @default.
- W2034880050 hasConceptScore W2034880050C12554922 @default.
- W2034880050 hasConceptScore W2034880050C170493617 @default.
- W2034880050 hasConceptScore W2034880050C178790620 @default.
- W2034880050 hasConceptScore W2034880050C185592680 @default.
- W2034880050 hasConceptScore W2034880050C2777339483 @default.
- W2034880050 hasConceptScore W2034880050C2779133857 @default.
- W2034880050 hasConceptScore W2034880050C512185932 @default.
- W2034880050 hasConceptScore W2034880050C537181965 @default.
- W2034880050 hasConceptScore W2034880050C55493867 @default.
- W2034880050 hasConceptScore W2034880050C71240020 @default.
- W2034880050 hasConceptScore W2034880050C74998103 @default.
- W2034880050 hasConceptScore W2034880050C86803240 @default.
- W2034880050 hasIssue "3" @default.
- W2034880050 hasLocation W20348800501 @default.
- W2034880050 hasLocation W20348800502 @default.
- W2034880050 hasOpenAccess W2034880050 @default.
- W2034880050 hasPrimaryLocation W20348800501 @default.
- W2034880050 hasRelatedWork W1569123141 @default.
- W2034880050 hasRelatedWork W1971031067 @default.
- W2034880050 hasRelatedWork W1973100544 @default.
- W2034880050 hasRelatedWork W1974664442 @default.
- W2034880050 hasRelatedWork W1974978789 @default.