Matches in SemOpenAlex for { <https://semopenalex.org/work/W203488111> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W203488111 endingPage "401" @default.
- W203488111 startingPage "397" @default.
- W203488111 abstract "The induction of prolactin (PRL)-gene expression by calcitriol (1,25-dihydroxyvitamin D3, 1,25-dihydroxycholecalciferol) in clonal rat pituitary tumour (GH4C1) cells was selectively inhibited by cortisol [IC50 (concentration causing 50% inhibition) = 3.2-4.1 nM]. The steroid specificity of this effect was investigated and various steroids were found to inhibit calcitriol-stimulated PRL production with the following relative potencies: cortisol, 1; dexamethasone, 8; 11-deoxycortisol, 0.5; corticosterone, 0.4; aldosterone, 0.07; testosterone and oestradiol, less than 0.003. The steroid antagonist RU 38486 did not affect basal or calcitriol-stimulated PRL production, but antagonized the effect of 10 nM-cortisol in a concentration-dependent manner. Neither progesterone nor 11-deoxycortisol antagonized the effect of 10 nM-cortisol. Calcitriol-induced PRL production was 14 times more sensitive to dexamethasone inhibition than was non-stimulated PRL production. Growth-hormone production was stimulated by dexamethasone, in the presence or absence of calcitriol, with a concentration-dependence similar to that of dexamethasone inhibition of basal PRL production. These data indicate that steroid inhibition of calcitriol-stimulated PRL production is a specific glucocorticoid effect. The sensitivity of calcitriol-stimulated PRL production to dexamethasone was 14-26-fold greater than that of other measured responses in the same cells. Two of the possible explanations for this selectively increased sensitivity to glucocorticoids are: amplification of the glucocorticoid effect via an induced mediator; and the presence of very-high-affinity glucocorticoid-receptor-binding sites on DNA." @default.
- W203488111 created "2016-06-24" @default.
- W203488111 creator A5012045230 @default.
- W203488111 creator A5016560016 @default.
- W203488111 date "1987-01-15" @default.
- W203488111 modified "2023-10-14" @default.
- W203488111 title "Steroid inhibition of calcitriol-induced prolactin production in GH4C1 cells. Specificity and sensitivity" @default.
- W203488111 cites W123333279 @default.
- W203488111 cites W1519455435 @default.
- W203488111 cites W1521356588 @default.
- W203488111 cites W1795742627 @default.
- W203488111 cites W1965088003 @default.
- W203488111 cites W1990524094 @default.
- W203488111 cites W2011458468 @default.
- W203488111 cites W2014943183 @default.
- W203488111 cites W2019550138 @default.
- W203488111 cites W2051176657 @default.
- W203488111 cites W2056514569 @default.
- W203488111 cites W2071648206 @default.
- W203488111 cites W2080580789 @default.
- W203488111 cites W2092885656 @default.
- W203488111 cites W2128635872 @default.
- W203488111 cites W2150513416 @default.
- W203488111 doi "https://doi.org/10.1042/bj2410397" @default.
- W203488111 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1147573" @default.
- W203488111 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3593199" @default.
- W203488111 hasPublicationYear "1987" @default.
- W203488111 type Work @default.
- W203488111 sameAs 203488111 @default.
- W203488111 citedByCount "3" @default.
- W203488111 crossrefType "journal-article" @default.
- W203488111 hasAuthorship W203488111A5012045230 @default.
- W203488111 hasAuthorship W203488111A5016560016 @default.
- W203488111 hasBestOaLocation W2034881112 @default.
- W203488111 hasConcept C124490489 @default.
- W203488111 hasConcept C126322002 @default.
- W203488111 hasConcept C134018914 @default.
- W203488111 hasConcept C185592680 @default.
- W203488111 hasConcept C2776079296 @default.
- W203488111 hasConcept C2776888042 @default.
- W203488111 hasConcept C2779064019 @default.
- W203488111 hasConcept C2780004078 @default.
- W203488111 hasConcept C2780352252 @default.
- W203488111 hasConcept C2780401358 @default.
- W203488111 hasConcept C2780841215 @default.
- W203488111 hasConcept C2780902042 @default.
- W203488111 hasConcept C59493245 @default.
- W203488111 hasConcept C71315377 @default.
- W203488111 hasConcept C71924100 @default.
- W203488111 hasConcept C86803240 @default.
- W203488111 hasConceptScore W203488111C124490489 @default.
- W203488111 hasConceptScore W203488111C126322002 @default.
- W203488111 hasConceptScore W203488111C134018914 @default.
- W203488111 hasConceptScore W203488111C185592680 @default.
- W203488111 hasConceptScore W203488111C2776079296 @default.
- W203488111 hasConceptScore W203488111C2776888042 @default.
- W203488111 hasConceptScore W203488111C2779064019 @default.
- W203488111 hasConceptScore W203488111C2780004078 @default.
- W203488111 hasConceptScore W203488111C2780352252 @default.
- W203488111 hasConceptScore W203488111C2780401358 @default.
- W203488111 hasConceptScore W203488111C2780841215 @default.
- W203488111 hasConceptScore W203488111C2780902042 @default.
- W203488111 hasConceptScore W203488111C59493245 @default.
- W203488111 hasConceptScore W203488111C71315377 @default.
- W203488111 hasConceptScore W203488111C71924100 @default.
- W203488111 hasConceptScore W203488111C86803240 @default.
- W203488111 hasIssue "2" @default.
- W203488111 hasLocation W2034881111 @default.
- W203488111 hasLocation W2034881112 @default.
- W203488111 hasLocation W2034881113 @default.
- W203488111 hasLocation W2034881114 @default.
- W203488111 hasOpenAccess W203488111 @default.
- W203488111 hasPrimaryLocation W2034881111 @default.
- W203488111 hasRelatedWork W1970091690 @default.
- W203488111 hasRelatedWork W1999156064 @default.
- W203488111 hasRelatedWork W2023696391 @default.
- W203488111 hasRelatedWork W2031062169 @default.
- W203488111 hasRelatedWork W2034277681 @default.
- W203488111 hasRelatedWork W2055297180 @default.
- W203488111 hasRelatedWork W2098663397 @default.
- W203488111 hasRelatedWork W2138895519 @default.
- W203488111 hasRelatedWork W2170009663 @default.
- W203488111 hasRelatedWork W2170790420 @default.
- W203488111 hasVolume "241" @default.
- W203488111 isParatext "false" @default.
- W203488111 isRetracted "false" @default.
- W203488111 magId "203488111" @default.
- W203488111 workType "article" @default.