FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034882120> ?p ?o ?g. }

• W2034882120 abstract "Postoperative nausea and vomiting (PONV) is one of the most common and undesirable complaints recorded in as many as 70-80% of high-risk surgical patients. The current prophylactic therapy recommendations for PONV management stated in the Society of Ambulatory Anesthesia (SAMBA) guidelines should start with monotherapy and patients at moderate to high risk, a combination of antiemetic medication should be considered. Consequently, if rescue medication is required, the antiemetic drug chosen should be from a different therapeutic class and administration mode than the drug used for prophylaxis. The guidelines restrict the use of dexamethasone, transdermal scopolamine, aprepitant, and palonosetron as rescue medication 6 h after surgery. In an effort to find a safer and reliable therapy for PONV, new drugs with antiemetic properties and minimal side effects are needed, and scopolamine may be considered an effective alternative. Scopolamine is a belladonna alkaloid, α-(hydroxymethyl) benzene acetic acid 9-methyl-3-oxa-9-azatricyclo non-7-yl ester, acting as a non-selective muscarinic antagonist and producing both peripheral antimuscarinic and central sedative, antiemetic, and amnestic effects. The empirical formula is C17H21NO4 and its structural formula is a tertiary amine L-(2)-scopolamine (tropic acid ester with scopine; MW = 303.4). Scopolamine became the first drug commercially available as a transdermal therapeutic system used for extended continuous drug delivery during 72 h. Clinical trials with transdermal scopolamine have consistently demonstrated its safety and efficacy in PONV. Thus, scopolamine is a promising candidate for the management of PONV in adults as a first line monotherapy or in combination with other drugs. In addition, transdermal scopolamine might be helpful in preventing postoperative discharge nausea and vomiting owing to its long-lasting clinical effects." @default.
• W2034882120 created "2016-06-24" @default.
• W2034882120 creator A5020819553 @default.
• W2034882120 creator A5028131864 @default.
• W2034882120 creator A5033526083 @default.
• W2034882120 creator A5039382366 @default.
• W2034882120 creator A5040109608 @default.
• W2034882120 creator A5053697923 @default.
• W2034882120 creator A5062494014 @default.
• W2034882120 date "2014-04-09" @default.
• W2034882120 modified "2023-10-17" @default.
• W2034882120 title "The effect of transdermal scopolamine for the prevention of postoperative nausea and vomiting" @default.
• W2034882120 cites W140691243 @default.
• W2034882120 cites W1616871482 @default.
• W2034882120 cites W1993015585 @default.
• W2034882120 cites W2008322120 @default.
• W2034882120 cites W2009102125 @default.
• W2034882120 cites W2010099999 @default.
• W2034882120 cites W2010901658 @default.
• W2034882120 cites W2015117488 @default.
• W2034882120 cites W2019007378 @default.
• W2034882120 cites W2021631141 @default.
• W2034882120 cites W2027206415 @default.
• W2034882120 cites W2027351891 @default.
• W2034882120 cites W2030800091 @default.
• W2034882120 cites W2034100536 @default.
• W2034882120 cites W2037016226 @default.
• W2034882120 cites W2046129827 @default.
• W2034882120 cites W2062207107 @default.
• W2034882120 cites W2067205748 @default.
• W2034882120 cites W2068669697 @default.
• W2034882120 cites W2076033624 @default.
• W2034882120 cites W2088354687 @default.
• W2034882120 cites W2109307601 @default.
• W2034882120 cites W2113402975 @default.
• W2034882120 cites W2131118318 @default.
• W2034882120 cites W2138209059 @default.
• W2034882120 cites W2157637320 @default.
• W2034882120 doi "https://doi.org/10.3389/fphar.2014.00055" @default.
• W2034882120 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3988383" @default.
• W2034882120 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24782768" @default.
• W2034882120 hasPublicationYear "2014" @default.
• W2034882120 type Work @default.
• W2034882120 sameAs 2034882120 @default.
• W2034882120 citedByCount "40" @default.
• W2034882120 countsByYear W20348821202014 @default.
• W2034882120 countsByYear W20348821202015 @default.
• W2034882120 countsByYear W20348821202016 @default.
• W2034882120 countsByYear W20348821202017 @default.
• W2034882120 countsByYear W20348821202018 @default.
• W2034882120 countsByYear W20348821202019 @default.
• W2034882120 countsByYear W20348821202020 @default.
• W2034882120 countsByYear W20348821202021 @default.
• W2034882120 countsByYear W20348821202022 @default.
• W2034882120 countsByYear W20348821202023 @default.
• W2034882120 crossrefType "journal-article" @default.
• W2034882120 hasAuthorship W2034882120A5020819553 @default.
• W2034882120 hasAuthorship W2034882120A5028131864 @default.
• W2034882120 hasAuthorship W2034882120A5033526083 @default.
• W2034882120 hasAuthorship W2034882120A5039382366 @default.
• W2034882120 hasAuthorship W2034882120A5040109608 @default.
• W2034882120 hasAuthorship W2034882120A5053697923 @default.
• W2034882120 hasAuthorship W2034882120A5062494014 @default.
• W2034882120 hasBestOaLocation W20348821201 @default.
• W2034882120 hasConcept C205679159 @default.
• W2034882120 hasConcept C2777297131 @default.
• W2034882120 hasConcept C2778689640 @default.
• W2034882120 hasConcept C2780580376 @default.
• W2034882120 hasConcept C2780852908 @default.
• W2034882120 hasConcept C2780884295 @default.
• W2034882120 hasConcept C42219234 @default.
• W2034882120 hasConcept C71924100 @default.
• W2034882120 hasConcept C98274493 @default.
• W2034882120 hasConceptScore W2034882120C205679159 @default.
• W2034882120 hasConceptScore W2034882120C2777297131 @default.
• W2034882120 hasConceptScore W2034882120C2778689640 @default.
• W2034882120 hasConceptScore W2034882120C2780580376 @default.
• W2034882120 hasConceptScore W2034882120C2780852908 @default.
• W2034882120 hasConceptScore W2034882120C2780884295 @default.
• W2034882120 hasConceptScore W2034882120C42219234 @default.
• W2034882120 hasConceptScore W2034882120C71924100 @default.
• W2034882120 hasConceptScore W2034882120C98274493 @default.
• W2034882120 hasLocation W20348821201 @default.
• W2034882120 hasLocation W20348821202 @default.
• W2034882120 hasLocation W20348821203 @default.
• W2034882120 hasLocation W20348821204 @default.
• W2034882120 hasLocation W20348821205 @default.
• W2034882120 hasOpenAccess W2034882120 @default.
• W2034882120 hasPrimaryLocation W20348821201 @default.
• W2034882120 hasRelatedWork W128791138 @default.
• W2034882120 hasRelatedWork W1983567324 @default.
• W2034882120 hasRelatedWork W2002240263 @default.
• W2034882120 hasRelatedWork W2007857130 @default.
• W2034882120 hasRelatedWork W2018715784 @default.
• W2034882120 hasRelatedWork W2044518447 @default.
• W2034882120 hasRelatedWork W2080737390 @default.
• W2034882120 hasRelatedWork W2165031861 @default.
• W2034882120 hasRelatedWork W2319545562 @default.
• W2034882120 hasRelatedWork W2799565947 @default.
• W2034882120 hasVolume "5" @default.

• next