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W2034882151 abstract "Insulin-dependent diabetes mellitus results from the autoimmune destruction of the insulin-producing beta cells of the pancreatic islets. The target antigen(s) involved in this immunopathological process has not been identified. Our strategy was to determine whether expression of a novel surface antigen by murine pancreatic beta cells would result in insulin-dependent diabetes mellitus. We have generated lines of transgenic mice (RIP-HA) that express the hemagglutinin of the A/Japan/305/57 strain of influenza virus on their insulin-producing beta cells. Hyperglycemia developed in mice derived from all three founders at a frequency varying from 13% to 27%, and was associated with lymphocytic infiltration of the islets and a humoral response against beta cell antigens, including hemagglutinin. These results suggest that the RIP-HA mice should provide a useful system in which to study the cellular interactions involved in the induction of self-tolerance and autoimmunity." @default.
W2034882151 created "2016-06-24" @default.
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W2034882151 date "1990-05-01" @default.
W2034882151 modified "2023-10-15" @default.
W2034882151 title "The expression of influenza virus hemagglutinin in the pancreatic β cells of transgenic mice results in autoimmune diabetes" @default.
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W2034882151 doi "https://doi.org/10.1016/0092-8674(90)90521-f" @default.
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