FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034882386> ?p ?o ?g. }

• W2034882386 endingPage "467" @default.
• W2034882386 startingPage "460" @default.
• W2034882386 abstract "Fumaric acid esters (FAE) are used for the systemic therapy of psoriasis and are now considered for the treatment of autoimmune-based neurological disorders such as multiple sclerosis. Currently, the cellular metabolism of FAE as well as the mechanisms of their therapeutic action are poorly understood. Since cellular glutathione (GSH) is involved in the detoxification of xenobiotics, we analysed the consequences of an application of FAE on the content of GSH in brain cells using astroglia-rich primary cultures as model system. Micromolar concentrations of dimethyl fumarate (DMF) or diethyl fumarate (DEF) lowered the cellular GSH content in a time- and concentration-dependent manner. Halfmaximal effects after 60 min of incubation were observed for 10 microM DMF or DEF. In contrast to the diesters, monomethyl fumarate (MMF), monoethyl fumarate (MEF) or fumarate had to be applied in concentrations of 10 mM for 60 min to significantly lower the cellular GSH content. During 60 min exposure, DMF or DEF did not significantly affect the cell viability, increase the cellular content of glutathione disulfide, nor altered the specific activities of glucose-6-phosphate dehydrogenase, glutathione reductase, or lactate dehydrogenase. After removal of DMF or DEF, cultured astrocytes restored their cellular GSH content completely within 4h. These data demonstrate that acute exposure to fumaric acid diesters deprives astrocytes of their GSH, most likely by the reaction of the reactive alpha,beta-unsaturated diesters with GSH." @default.
• W2034882386 created "2016-06-24" @default.
• W2034882386 creator A5014772212 @default.
• W2034882386 creator A5077770397 @default.
• W2034882386 date "2010-11-01" @default.
• W2034882386 modified "2023-10-03" @default.
• W2034882386 title "Fumaric acid diesters deprive cultured primary astrocytes rapidly of glutathione" @default.
• W2034882386 cites W1259543534 @default.
• W2034882386 cites W1483126537 @default.
• W2034882386 cites W1486228890 @default.
• W2034882386 cites W1509452365 @default.
• W2034882386 cites W1519205980 @default.
• W2034882386 cites W1558564171 @default.
• W2034882386 cites W1565537222 @default.
• W2034882386 cites W1673039816 @default.
• W2034882386 cites W1775749144 @default.
• W2034882386 cites W1873279410 @default.
• W2034882386 cites W1874765914 @default.
• W2034882386 cites W1970068928 @default.
• W2034882386 cites W1971328602 @default.
• W2034882386 cites W1971470223 @default.
• W2034882386 cites W1978916589 @default.
• W2034882386 cites W1981820162 @default.
• W2034882386 cites W1982651534 @default.
• W2034882386 cites W1983594598 @default.
• W2034882386 cites W1985948217 @default.
• W2034882386 cites W1989614044 @default.
• W2034882386 cites W1992298869 @default.
• W2034882386 cites W1993480898 @default.
• W2034882386 cites W1993802774 @default.
• W2034882386 cites W1994032593 @default.
• W2034882386 cites W1995370236 @default.
• W2034882386 cites W2003598937 @default.
• W2034882386 cites W2007064404 @default.
• W2034882386 cites W2007085965 @default.
• W2034882386 cites W2007699204 @default.
• W2034882386 cites W2012165445 @default.
• W2034882386 cites W2021705440 @default.
• W2034882386 cites W2022260179 @default.
• W2034882386 cites W2025234510 @default.
• W2034882386 cites W2030843726 @default.
• W2034882386 cites W2031925716 @default.
• W2034882386 cites W2033415076 @default.
• W2034882386 cites W2037048256 @default.
• W2034882386 cites W2040031023 @default.
• W2034882386 cites W2040601222 @default.
• W2034882386 cites W2041414417 @default.
• W2034882386 cites W2041803321 @default.
• W2034882386 cites W2049225057 @default.
• W2034882386 cites W2070123215 @default.
• W2034882386 cites W2071270895 @default.
• W2034882386 cites W2095368541 @default.
• W2034882386 cites W2095411323 @default.
• W2034882386 cites W2097317964 @default.
• W2034882386 cites W2124417387 @default.
• W2034882386 cites W2131059217 @default.
• W2034882386 cites W2136687695 @default.
• W2034882386 cites W2150559732 @default.
• W2034882386 cites W2153124797 @default.
• W2034882386 cites W2153353636 @default.
• W2034882386 cites W2169714384 @default.
• W2034882386 cites W2169812410 @default.
• W2034882386 doi "https://doi.org/10.1016/j.neuint.2010.01.006" @default.
• W2034882386 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20096739" @default.
• W2034882386 hasPublicationYear "2010" @default.
• W2034882386 type Work @default.
• W2034882386 sameAs 2034882386 @default.
• W2034882386 citedByCount "54" @default.
• W2034882386 countsByYear W20348823862012 @default.
• W2034882386 countsByYear W20348823862013 @default.
• W2034882386 countsByYear W20348823862014 @default.
• W2034882386 countsByYear W20348823862015 @default.
• W2034882386 countsByYear W20348823862016 @default.
• W2034882386 countsByYear W20348823862017 @default.
• W2034882386 countsByYear W20348823862018 @default.
• W2034882386 countsByYear W20348823862019 @default.
• W2034882386 countsByYear W20348823862020 @default.
• W2034882386 countsByYear W20348823862021 @default.
• W2034882386 countsByYear W20348823862022 @default.
• W2034882386 countsByYear W20348823862023 @default.
• W2034882386 crossrefType "journal-article" @default.
• W2034882386 hasAuthorship W2034882386A5014772212 @default.
• W2034882386 hasAuthorship W2034882386A5077770397 @default.
• W2034882386 hasConcept C165069038 @default.
• W2034882386 hasConcept C181199279 @default.
• W2034882386 hasConcept C185592680 @default.
• W2034882386 hasConcept C203014093 @default.
• W2034882386 hasConcept C2776163829 @default.
• W2034882386 hasConcept C2776819417 @default.
• W2034882386 hasConcept C2777318727 @default.
• W2034882386 hasConcept C2778760513 @default.
• W2034882386 hasConcept C2779179908 @default.
• W2034882386 hasConcept C2780640218 @default.
• W2034882386 hasConcept C538909803 @default.
• W2034882386 hasConcept C55493867 @default.
• W2034882386 hasConcept C62231903 @default.
• W2034882386 hasConcept C86803240 @default.
• W2034882386 hasConceptScore W2034882386C165069038 @default.

• next