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• W2034882509 abstract "A five year prospective study was conducted on 733 patients admitted to Memorial Sloan-Kettering Cancer Center with a single primary epidermoid carcinoma of the oral cavity, pharynx or larynx, diagnosed between 1965 and 1968. The survival in women at five years following diagnosis of the index cancer was significantly better than in men. The average annual incidence for second primary carcinomas of the respiratory and upper digestive systems was 18.2 per 1000 in men and 15.4 per 1000 in women. The women were distinguished from the men by their less intensive exposure to tobacco and alcohol previous to the index cancer. The risk of developing a second primary cancer was enhanced significantly by more intensive, combined exposures to tobacco and alcohol prior to the index cancer. Within the first five years after the clinical presentation of the index cancer, the development of any new neoplastic process previously initiated in the exposed tissues was unaffected by altered smoking and drinking habits after the index cancer. Of the 433 deaths occurring at five years in the study population, two-thirds were attributed to metastases or the complications of treatment of a single or multiple primary cancer of the oral cavity, pharynx or larynx, 1.5% to a new primary cancer of the lung or esophagus and 1.4% to a new primary cancer of an organ outside of the respiratory and upper digestive tracts. The significant excesses in cancer mortality in men and women were particularly evident between 45–64 years of age and were distributed throughout all levels of exposure to tobacco and alcohol. The underlying cause in 30.7% was due to diseases other than cancer. Future follow-up will enable us to determine the risk of new primary cancers and intercurrent nonneoplastic diseases in patients who continue to smoke and/or drink, and whether these risks, as suggested by our retrospective study, are enhanced as a result of previous radiation therapy." @default.
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• W2034882509 date "1974-06-01" @default.
• W2034882509 modified "2023-10-17" @default.
• W2034882509 title "The role of alcohol and tobacco in multiple primary cancers of the upper digestive system, larynx and lung: A prospective study" @default.
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• W2034882509 doi "https://doi.org/10.1016/0091-7435(74)90037-1" @default.
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