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- W2034882585 abstract "Tumor necrosis factor-α (TNF-α) induces apoptosis predominantly via TNF-receptor I (TNF-RI). We have examined the molecular and biochemical pathways of TNF-α-induced apoptosis in T cells from aged and young subjects. Aged subjects show absolute lymphopenia and decreased numbers of both CD4+ and CD8+ T cells. T cells from aged subjects show increased sensitivity to TNF-α-induced apoptosis that is associated with increased expression of TNF-RI and decreased expression of TNF-RII in both CD4+ and CD8+ T cells. Agonistic TNF-RI also induced greater apoptosis in T cells from aged subjects as compared to young subjects, suggesting that increased TNF-α-induced apoptosis in aging is predominantly mediated via TNF-RI. There was an increased expression of FADD and increased activation of caspase 8 and caspase 3 in lymphocytes from aged humans as compared to young subjects. A role of impaired TNF-RII-mediated signaling in increased apoptosis in aged subjects is also discussed." @default.
- W2034882585 created "2016-06-24" @default.
- W2034882585 creator A5058987519 @default.
- W2034882585 date "2002-01-01" @default.
- W2034882585 modified "2023-10-17" @default.
- W2034882585 title "Tumor necrosis factor-α-induced apoptosis in T cells from aged humans: a role of TNFR-I and downstream signaling molecules" @default.
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- W2034882585 doi "https://doi.org/10.1016/s0531-5565(01)00195-4" @default.
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