FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034883412> ?p ?o ?g. }

• W2034883412 endingPage "3519" @default.
• W2034883412 startingPage "3511" @default.
• W2034883412 abstract "Aspergillus fumigatus grows well at neutral and acidic pH in a medium containing protein as the sole nitrogen source by secreting two different sets of proteases. Neutral pH favors the secretion of neutral and alkaline endoproteases, leucine aminopeptidases (Laps) which are nonspecific monoaminopeptidases, and an X-prolyl dipeptidase (DppIV). Acidic pH environment promotes the secretion of an aspartic endoprotease of pepsin family (Pep1) and tripeptidyl-peptidases of the sedolisin family (SedB and SedD). A novel prolyl peptidase, AfuS28, was found to be secreted in both alkaline and acidic conditions. In previous studies, Laps were shown to degrade peptides from their N-terminus until an X-Pro sequence acts as a stop signal. X-Pro sequences can be then removed by DppIV, which allows Laps access to the following residues. We have shown that at acidic pH Seds degrade large peptides from their N-terminus into tripeptides until Pro in P1 or P'1 position acts as a stop for these exopeptidases. However, X-X-Pro and X-X-X-Pro sequences can be removed by AfuS28 thus allowing Seds further sequential proteolysis. In conclusion, both alkaline and acidic sets of proteases contain exoprotease activity capable of cleaving after proline residues that cannot be removed during sequential digestion by nonspecific exopeptidases." @default.
• W2034883412 created "2016-06-24" @default.
• W2034883412 creator A5016061371 @default.
• W2034883412 creator A5029586330 @default.
• W2034883412 creator A5039143614 @default.
• W2034883412 creator A5049875603 @default.
• W2034883412 creator A5069085364 @default.
• W2034883412 creator A5069847951 @default.
• W2034883412 creator A5077227657 @default.
• W2034883412 creator A5085992500 @default.
• W2034883412 date "2010-06-03" @default.
• W2034883412 modified "2023-09-26" @default.
• W2034883412 title "<i>Aspergillus</i> Protein Degradation Pathways with Different Secreted Protease Sets at Neutral and Acidic pH" @default.
• W2034883412 cites W1493194262 @default.
• W2034883412 cites W1538699360 @default.
• W2034883412 cites W1966809971 @default.
• W2034883412 cites W1967954749 @default.
• W2034883412 cites W1997504014 @default.
• W2034883412 cites W2005285337 @default.
• W2034883412 cites W2015556811 @default.
• W2034883412 cites W2030631510 @default.
• W2034883412 cites W2031062086 @default.
• W2034883412 cites W2033493201 @default.
• W2034883412 cites W2037658219 @default.
• W2034883412 cites W2051870369 @default.
• W2034883412 cites W2052108603 @default.
• W2034883412 cites W2053480301 @default.
• W2034883412 cites W2054537975 @default.
• W2034883412 cites W2076045144 @default.
• W2034883412 cites W2078594804 @default.
• W2034883412 cites W2095652159 @default.
• W2034883412 cites W2095810035 @default.
• W2034883412 cites W2101629470 @default.
• W2034883412 cites W2112078820 @default.
• W2034883412 cites W2116213013 @default.
• W2034883412 cites W2124814621 @default.
• W2034883412 cites W2125968920 @default.
• W2034883412 cites W2130497216 @default.
• W2034883412 cites W2137959581 @default.
• W2034883412 cites W2138879032 @default.
• W2034883412 cites W2139026026 @default.
• W2034883412 cites W2142889585 @default.
• W2034883412 cites W2144526814 @default.
• W2034883412 cites W2146925163 @default.
• W2034883412 cites W2151535112 @default.
• W2034883412 cites W2153911335 @default.
• W2034883412 cites W2157885858 @default.
• W2034883412 cites W2161746138 @default.
• W2034883412 cites W2163472079 @default.
• W2034883412 cites W4242086928 @default.
• W2034883412 doi "https://doi.org/10.1021/pr901202z" @default.
• W2034883412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20486678" @default.
• W2034883412 hasPublicationYear "2010" @default.
• W2034883412 type Work @default.
• W2034883412 sameAs 2034883412 @default.
• W2034883412 citedByCount "50" @default.
• W2034883412 countsByYear W20348834122012 @default.
• W2034883412 countsByYear W20348834122013 @default.
• W2034883412 countsByYear W20348834122014 @default.
• W2034883412 countsByYear W20348834122015 @default.
• W2034883412 countsByYear W20348834122016 @default.
• W2034883412 countsByYear W20348834122017 @default.
• W2034883412 countsByYear W20348834122018 @default.
• W2034883412 countsByYear W20348834122019 @default.
• W2034883412 countsByYear W20348834122020 @default.
• W2034883412 countsByYear W20348834122021 @default.
• W2034883412 countsByYear W20348834122022 @default.
• W2034883412 countsByYear W20348834122023 @default.
• W2034883412 crossrefType "journal-article" @default.
• W2034883412 hasAuthorship W2034883412A5016061371 @default.
• W2034883412 hasAuthorship W2034883412A5029586330 @default.
• W2034883412 hasAuthorship W2034883412A5039143614 @default.
• W2034883412 hasAuthorship W2034883412A5049875603 @default.
• W2034883412 hasAuthorship W2034883412A5069085364 @default.
• W2034883412 hasAuthorship W2034883412A5069847951 @default.
• W2034883412 hasAuthorship W2034883412A5077227657 @default.
• W2034883412 hasAuthorship W2034883412A5085992500 @default.
• W2034883412 hasConcept C181199279 @default.
• W2034883412 hasConcept C182220744 @default.
• W2034883412 hasConcept C185592680 @default.
• W2034883412 hasConcept C2776580952 @default.
• W2034883412 hasConcept C2776714187 @default.
• W2034883412 hasConcept C2780985610 @default.
• W2034883412 hasConcept C2781307694 @default.
• W2034883412 hasConcept C49039625 @default.
• W2034883412 hasConcept C515207424 @default.
• W2034883412 hasConcept C54374919 @default.
• W2034883412 hasConcept C55493867 @default.
• W2034883412 hasConcept C80458899 @default.
• W2034883412 hasConcept C86803240 @default.
• W2034883412 hasConceptScore W2034883412C181199279 @default.
• W2034883412 hasConceptScore W2034883412C182220744 @default.
• W2034883412 hasConceptScore W2034883412C185592680 @default.
• W2034883412 hasConceptScore W2034883412C2776580952 @default.
• W2034883412 hasConceptScore W2034883412C2776714187 @default.
• W2034883412 hasConceptScore W2034883412C2780985610 @default.
• W2034883412 hasConceptScore W2034883412C2781307694 @default.
• W2034883412 hasConceptScore W2034883412C49039625 @default.

• next