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• W2034883902 abstract "Analysis of databases from transplant recipients revealed a 3–5 fold higher risk to develop de novo malignancies under continued immunosuppression. The underlying mechanisms are poorly understood. Here we describe a patient who received a bilateral lung transplantation for end-stage ‘Usual Interstitial Pneumonia’ (UIP) resulting in idiopathic lung fibrosis. The recipient presented with a non-small cell lung carcinoma (NSCLC) in the donor lung 7 months later. Molecular and immunological typing of the tumor revealed a cancer of donor origin with a prominent intratumoral immune cell infiltrate without detectable effector function. This is a unique case of de novo outgrowth of a NSCLC of donor origin under continued immunosuppression, supporting the concept of tumor immunosurveillance in vivo." @default.
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• W2034883902 date "2012-04-01" @default.
• W2034883902 modified "2023-09-28" @default.
• W2034883902 title "Immunosuppression and lung cancer of donor origin after bilateral lung transplantation" @default.
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• W2034883902 doi "https://doi.org/10.1016/j.lungcan.2011.10.001" @default.
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