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• W2034884509 abstract "Chondrocytes and synoviocytes harvested from the joints of healthy horses were maintained in tissue culture. Production of the cytokines interleukin‐1 (IL‐1), interleukin‐6 (IL‐6) and tumour necrosis factor‐ α (TNF‐ α ) in response to lipopolysaccharide (LPS), and the effects of addition of carprofen (racemate and R and S enantiomers) were determined. Lipopolysaccharide failed to stimulate TNF‐ α activity in both cell types but concentrations of IL‐1 and IL‐6 were both increased in a concentration and time‐related manner. Both carprofen enantiomers and the racemic mixture attenuated the increase in IL‐6 induced by LPS in synoviocytes, and S carprofen exerted a similar effect on chondrocytes. Neither enantiomer nor the racemate of carprofen suppressed the increase in IL‐1 release produced by LPS in chondrocytes and synoviocytes. An action of carprofen to suppress IL‐6 release might contribute to the actions which occur in vivo ." @default.
• W2034884509 created "2016-06-24" @default.
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• W2034884509 date "2002-04-01" @default.
• W2034884509 modified "2023-10-18" @default.
• W2034884509 title "Effects of carprofen (R and S enantiomers and racemate) on the production of IL-1, IL-6 and TNF-alpha by equine chondrocytes and synoviocytes" @default.
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• W2034884509 doi "https://doi.org/10.1046/j.1365-2885.2002.00397.x" @default.
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