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- W2034884528 abstract "Fibrillin molecules form the structural framework of elastic fibrillin‐rich microfibrils of the extracellular matrix. We have investigated the proteolysis of recombinant fibrillin molecules by five matrix metalloproteinases. Cleavage sites were defined at the carboxy‐terminal end of the fibrillin‐1 proline‐rich region and the corresponding fibrillin‐2 glycine‐rich region (exon 10), and within exon 49 towards the carboxy‐terminus of fibrillin‐1. Cleavage at these sites is predicted to disrupt the structure and function of the fibrillin‐rich microfibrils." @default.
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- W2034884528 date "1999-06-11" @default.
- W2034884528 modified "2023-10-14" @default.
- W2034884528 title "Fibrillin degradation by matrix metalloproteinases: identification of amino- and carboxy-terminal cleavage sites" @default.
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- W2034884528 doi "https://doi.org/10.1016/s0014-5793(99)00623-7" @default.
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