FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034884676> ?p ?o ?g. }

• W2034884676 endingPage "592" @default.
• W2034884676 startingPage "581" @default.
• W2034884676 abstract "The Rho family GTPase Cdc42 is a key regulator of cell polarity and cytoskeletal organization in eukaryotic cells. In yeast, the role of Cdc42 in polarization of cell growth includes polarization of the actin cytoskeleton, which delivers secretory vesicles to growth sites at the plasma membrane. We now describe a novel temperature-sensitive mutant, cdc42-6, that reveals a role for Cdc42 in docking and fusion of secretory vesicles that is independent of its role in actin polarization. cdc42-6 mutants can polarize actin and deliver secretory vesicles to the bud, but fail to fuse those vesicles with the plasma membrane. This defect is manifested only during the early stages of bud formation when growth is most highly polarized, and appears to reflect a requirement for Cdc42 to maintain maximally active exocytic machinery at sites of high vesicle throughput. Extensive genetic interactions between cdc42-6 and mutations in exocytic components support this hypothesis, and indicate a functional overlap with Rho3, which also regulates both actin organization and exocytosis. Localization data suggest that the defect in cdc42-6 cells is not at the level of the localization of the exocytic apparatus. Rather, we suggest that Cdc42 acts as an allosteric regulator of the vesicle docking and fusion apparatus to provide maximal function at sites of polarized growth." @default.
• W2034884676 created "2016-06-24" @default.
• W2034884676 creator A5014458109 @default.
• W2034884676 creator A5019437370 @default.
• W2034884676 creator A5019605898 @default.
• W2034884676 creator A5049394671 @default.
• W2034884676 creator A5068745055 @default.
• W2034884676 creator A5086058826 @default.
• W2034884676 date "2001-11-12" @default.
• W2034884676 modified "2023-10-01" @default.
• W2034884676 title "Yeast Cdc42 functions at a late step in exocytosis, specifically during polarized growth of the emerging bud" @default.
• W2034884676 cites W1492879782 @default.
• W2034884676 cites W1538303836 @default.
• W2034884676 cites W1570678799 @default.
• W2034884676 cites W1856070105 @default.
• W2034884676 cites W1942681839 @default.
• W2034884676 cites W1967716439 @default.
• W2034884676 cites W1973782344 @default.
• W2034884676 cites W1998062844 @default.
• W2034884676 cites W2001725097 @default.
• W2034884676 cites W2003345155 @default.
• W2034884676 cites W2007391251 @default.
• W2034884676 cites W2008429193 @default.
• W2034884676 cites W2013541506 @default.
• W2034884676 cites W2014307956 @default.
• W2034884676 cites W2014715442 @default.
• W2034884676 cites W2019488604 @default.
• W2034884676 cites W2030010219 @default.
• W2034884676 cites W2032817187 @default.
• W2034884676 cites W2036692489 @default.
• W2034884676 cites W2040169742 @default.
• W2034884676 cites W2049620445 @default.
• W2034884676 cites W2057163724 @default.
• W2034884676 cites W2060006253 @default.
• W2034884676 cites W2067354100 @default.
• W2034884676 cites W2069329269 @default.
• W2034884676 cites W2078188542 @default.
• W2034884676 cites W2082427481 @default.
• W2034884676 cites W2086121244 @default.
• W2034884676 cites W2086442201 @default.
• W2034884676 cites W2096533259 @default.
• W2034884676 cites W2098897758 @default.
• W2034884676 cites W2102748451 @default.
• W2034884676 cites W2109946302 @default.
• W2034884676 cites W2119065636 @default.
• W2034884676 cites W2119194326 @default.
• W2034884676 cites W2119905730 @default.
• W2034884676 cites W2122081057 @default.
• W2034884676 cites W2124650255 @default.
• W2034884676 cites W2140720186 @default.
• W2034884676 cites W2144833268 @default.
• W2034884676 cites W2149517464 @default.
• W2034884676 cites W2149668695 @default.
• W2034884676 cites W2152220855 @default.
• W2034884676 cites W2153763976 @default.
• W2034884676 cites W2154425220 @default.
• W2034884676 cites W2158726454 @default.
• W2034884676 cites W2160524202 @default.
• W2034884676 doi "https://doi.org/10.1083/jcb.200106065" @default.
• W2034884676 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2198861" @default.
• W2034884676 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11706050" @default.
• W2034884676 hasPublicationYear "2001" @default.
• W2034884676 type Work @default.
• W2034884676 sameAs 2034884676 @default.
• W2034884676 citedByCount "163" @default.
• W2034884676 countsByYear W20348846762012 @default.
• W2034884676 countsByYear W20348846762013 @default.
• W2034884676 countsByYear W20348846762014 @default.
• W2034884676 countsByYear W20348846762015 @default.
• W2034884676 countsByYear W20348846762016 @default.
• W2034884676 countsByYear W20348846762017 @default.
• W2034884676 countsByYear W20348846762018 @default.
• W2034884676 countsByYear W20348846762019 @default.
• W2034884676 countsByYear W20348846762020 @default.
• W2034884676 countsByYear W20348846762021 @default.
• W2034884676 countsByYear W20348846762022 @default.
• W2034884676 countsByYear W20348846762023 @default.
• W2034884676 crossrefType "journal-article" @default.
• W2034884676 hasAuthorship W2034884676A5014458109 @default.
• W2034884676 hasAuthorship W2034884676A5019437370 @default.
• W2034884676 hasAuthorship W2034884676A5019605898 @default.
• W2034884676 hasAuthorship W2034884676A5049394671 @default.
• W2034884676 hasAuthorship W2034884676A5068745055 @default.
• W2034884676 hasAuthorship W2034884676A5086058826 @default.
• W2034884676 hasBestOaLocation W20348846761 @default.
• W2034884676 hasConcept C104317684 @default.
• W2034884676 hasConcept C125705527 @default.
• W2034884676 hasConcept C130316041 @default.
• W2034884676 hasConcept C142669718 @default.
• W2034884676 hasConcept C148785051 @default.
• W2034884676 hasConcept C1491633281 @default.
• W2034884676 hasConcept C156728348 @default.
• W2034884676 hasConcept C168197293 @default.
• W2034884676 hasConcept C175969161 @default.
• W2034884676 hasConcept C18903297 @default.
• W2034884676 hasConcept C196330066 @default.
• W2034884676 hasConcept C207332259 @default.
• W2034884676 hasConcept C2777407749 @default.

• next