FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034885237> ?p ?o ?g. }

• W2034885237 endingPage "8339" @default.
• W2034885237 startingPage "8330" @default.
• W2034885237 abstract "The ability of a transmembrane helix (TMH) to insert into a lipid bilayer has been mainly understood based on the total hydrophobicity of the peptide sequence. Recently, Hedin et al. investigated the influence of flanking loops on membrane insertion of a set of marginally hydrophobic TMHs using translocon-based membrane integration assays. While the flanking loops were found to facilitate the insertion in most cases, counter examples also emerged where the flanking loops hinder membrane insertion and contradict the hydrophobicity and charge distribution analyses. Here, coarse-grained free energy calculations and atomistic simulations were performed to investigate the energetics and conformational details of the membrane insertion of two representative marginally hydrophobic TMHs with (NhaL and EmrL) and without (NhaA and EmrD) the flanking loops. The simulations fail to directly recapitulate the contrasting effects of the flanking loops for these two TMHs, due to systematic overprediction of the stabilities of the transmembrane states that has also been consistently observed in previous studies. Nonetheless, detailed force decomposition and peptide conformation analyses suggest a novel mechanism on how the peptide conformational equilibrium in the aqueous phase may modulate the effects of flanking loops on membrane insertion. Specifically, the flanking loops in peptide EmrL interact strongly with the TMH segment and form stable compact conformations in the aqueous phase, which can hinder membrane absorption and insertion as these processes require extended conformations with minimal interactions between the flanking loops and TMH segment. This work also emphasizes the general importance of considering the peptide conformational equilibrium for understanding the mechanism and energetics of membrane insertion, an aspect that has not yet been sufficiently addressed in the literature." @default.
• W2034885237 created "2016-06-24" @default.
• W2034885237 creator A5032839759 @default.
• W2034885237 creator A5067823321 @default.
• W2034885237 date "2013-07-02" @default.
• W2034885237 modified "2023-10-17" @default.
• W2034885237 title "Effects of Flanking Loops on Membrane Insertion of Transmembrane Helices: A Role for Peptide Conformational Equilibrium" @default.
• W2034885237 cites W1512617141 @default.
• W2034885237 cites W1969455492 @default.
• W2034885237 cites W1971456069 @default.
• W2034885237 cites W1974030600 @default.
• W2034885237 cites W1976846652 @default.
• W2034885237 cites W1977859350 @default.
• W2034885237 cites W1981436290 @default.
• W2034885237 cites W1995827482 @default.
• W2034885237 cites W1996478334 @default.
• W2034885237 cites W1999133834 @default.
• W2034885237 cites W2002128187 @default.
• W2034885237 cites W2007961905 @default.
• W2034885237 cites W2007965478 @default.
• W2034885237 cites W2009133700 @default.
• W2034885237 cites W2019716888 @default.
• W2034885237 cites W2020570580 @default.
• W2034885237 cites W2023256284 @default.
• W2034885237 cites W2025859600 @default.
• W2034885237 cites W2026593599 @default.
• W2034885237 cites W2027296812 @default.
• W2034885237 cites W2027408247 @default.
• W2034885237 cites W2029667189 @default.
• W2034885237 cites W2034709522 @default.
• W2034885237 cites W2037803966 @default.
• W2034885237 cites W2044897724 @default.
• W2034885237 cites W2049286183 @default.
• W2034885237 cites W2050333027 @default.
• W2034885237 cites W2051864856 @default.
• W2034885237 cites W2057007235 @default.
• W2034885237 cites W2060097208 @default.
• W2034885237 cites W2061417691 @default.
• W2034885237 cites W2062709131 @default.
• W2034885237 cites W2066900663 @default.
• W2034885237 cites W2067174909 @default.
• W2034885237 cites W2068259203 @default.
• W2034885237 cites W2078481695 @default.
• W2034885237 cites W2078619116 @default.
• W2034885237 cites W2086714797 @default.
• W2034885237 cites W2093795463 @default.
• W2034885237 cites W2106140689 @default.
• W2034885237 cites W2107066422 @default.
• W2034885237 cites W2107317356 @default.
• W2034885237 cites W2112154906 @default.
• W2034885237 cites W2112769274 @default.
• W2034885237 cites W2119267663 @default.
• W2034885237 cites W2123075980 @default.
• W2034885237 cites W2132262459 @default.
• W2034885237 cites W2134762386 @default.
• W2034885237 cites W2144062946 @default.
• W2034885237 cites W2146923243 @default.
• W2034885237 cites W2150981663 @default.
• W2034885237 cites W2155147384 @default.
• W2034885237 cites W2160535028 @default.
• W2034885237 cites W2162166182 @default.
• W2034885237 cites W2162371743 @default.
• W2034885237 cites W2419396195 @default.
• W2034885237 cites W95860189 @default.
• W2034885237 doi "https://doi.org/10.1021/jp402356c" @default.
• W2034885237 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3754909" @default.
• W2034885237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23786317" @default.
• W2034885237 hasPublicationYear "2013" @default.
• W2034885237 type Work @default.
• W2034885237 sameAs 2034885237 @default.
• W2034885237 citedByCount "4" @default.
• W2034885237 countsByYear W20348852372014 @default.
• W2034885237 countsByYear W20348852372016 @default.
• W2034885237 crossrefType "journal-article" @default.
• W2034885237 hasAuthorship W2034885237A5032839759 @default.
• W2034885237 hasAuthorship W2034885237A5067823321 @default.
• W2034885237 hasBestOaLocation W20348852372 @default.
• W2034885237 hasConcept C118892022 @default.
• W2034885237 hasConcept C121332964 @default.
• W2034885237 hasConcept C12554922 @default.
• W2034885237 hasConcept C144647389 @default.
• W2034885237 hasConcept C147597530 @default.
• W2034885237 hasConcept C170493617 @default.
• W2034885237 hasConcept C185592680 @default.
• W2034885237 hasConcept C18903297 @default.
• W2034885237 hasConcept C192157962 @default.
• W2034885237 hasConcept C199229279 @default.
• W2034885237 hasConcept C24530287 @default.
• W2034885237 hasConcept C2778530040 @default.
• W2034885237 hasConcept C2779281246 @default.
• W2034885237 hasConcept C2779965526 @default.
• W2034885237 hasConcept C39944091 @default.
• W2034885237 hasConcept C41625074 @default.
• W2034885237 hasConcept C55493867 @default.
• W2034885237 hasConcept C59593255 @default.
• W2034885237 hasConcept C62520636 @default.
• W2034885237 hasConcept C8010536 @default.
• W2034885237 hasConcept C86803240 @default.

• next