FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034885923> ?p ?o ?g. }

• W2034885923 endingPage "1839" @default.
• W2034885923 startingPage "1832" @default.
• W2034885923 abstract "The biliary excretion of acetaminophen (APAP) is reduced in transport deficient (TR-) hyperbilirubinemic rats lacking the multidrug resistance-associated protein 2 (Mrp2). This mutant strain of Wistar rats has impaired biliary excretion of organic anions and increased hepatic glutathione. The rational for this study was to determine if there is an altered risk for liver damage by APAP in the absence of Mrp2. Therefore, the susceptibility of TR- rats to APAP hepatotoxicity was investigated. Male Wistar and TR- rats were fasted overnight before APAP treatment (1 g/kg). Hepatotoxicity was assessed 24 h later by plasma sorbitol dehydrogenase activity and histopathology. In other studies, TR- rats received buthionine sulfoximine before APAP to reduce hepatic glutathione to values similar to those in Wistar rats. mRNA expression of APAP metabolizing enzymes was also measured in naïve animals. Wistar rats treated with APAP showed significant elevations in plasma sorbitol dehydrogenase activity, while no increases in enzyme activity were observed in TR- rats. Histopathology was in agreement. Hepatic non-protein sulfhydryls were significantly lower in Wistar rats receiving APAP than in TR- rats. TR- rats treated with buthionine sulfoximine and APAP showed dramatic increases in hepatotoxicity. TR- rats had increased mRNA expression of several APAP metabolizing enzymes. Mrp2 expression not only is important in biliary excretion, but also influences the toxic potential of reactive intermediates by controlling intrahepatic GSH and possibly drug metabolism." @default.
• W2034885923 created "2016-06-24" @default.
• W2034885923 creator A5042547189 @default.
• W2034885923 creator A5062625465 @default.
• W2034885923 creator A5069084441 @default.
• W2034885923 creator A5088664957 @default.
• W2034885923 date "2005-12-01" @default.
• W2034885923 modified "2023-10-05" @default.
• W2034885923 title "Transport deficient (TR−) hyperbilirubinemic rats are resistant to acetaminophen hepatotoxicity" @default.
• W2034885923 cites W1508218230 @default.
• W2034885923 cites W1646404713 @default.
• W2034885923 cites W193327837 @default.
• W2034885923 cites W1938519122 @default.
• W2034885923 cites W1968425502 @default.
• W2034885923 cites W1973670220 @default.
• W2034885923 cites W1977842477 @default.
• W2034885923 cites W1979997292 @default.
• W2034885923 cites W1983548371 @default.
• W2034885923 cites W1984497947 @default.
• W2034885923 cites W1984613701 @default.
• W2034885923 cites W2006370393 @default.
• W2034885923 cites W2009145049 @default.
• W2034885923 cites W2019934265 @default.
• W2034885923 cites W2043420028 @default.
• W2034885923 cites W2046273424 @default.
• W2034885923 cites W2056293003 @default.
• W2034885923 cites W2074890587 @default.
• W2034885923 cites W2077358733 @default.
• W2034885923 cites W2083468617 @default.
• W2034885923 cites W2084535750 @default.
• W2034885923 cites W2085131512 @default.
• W2034885923 cites W2090175582 @default.
• W2034885923 cites W2094394245 @default.
• W2034885923 cites W2096872918 @default.
• W2034885923 cites W2104794215 @default.
• W2034885923 cites W2110118559 @default.
• W2034885923 cites W2139495786 @default.
• W2034885923 cites W2140403969 @default.
• W2034885923 cites W2154283357 @default.
• W2034885923 cites W2160960781 @default.
• W2034885923 doi "https://doi.org/10.1016/j.bcp.2005.09.024" @default.
• W2034885923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16271353" @default.
• W2034885923 hasPublicationYear "2005" @default.
• W2034885923 type Work @default.
• W2034885923 sameAs 2034885923 @default.
• W2034885923 citedByCount "16" @default.
• W2034885923 countsByYear W20348859232012 @default.
• W2034885923 countsByYear W20348859232013 @default.
• W2034885923 countsByYear W20348859232015 @default.
• W2034885923 countsByYear W20348859232017 @default.
• W2034885923 countsByYear W20348859232019 @default.
• W2034885923 countsByYear W20348859232022 @default.
• W2034885923 crossrefType "journal-article" @default.
• W2034885923 hasAuthorship W2034885923A5042547189 @default.
• W2034885923 hasAuthorship W2034885923A5062625465 @default.
• W2034885923 hasAuthorship W2034885923A5069084441 @default.
• W2034885923 hasAuthorship W2034885923A5088664957 @default.
• W2034885923 hasConcept C10146269 @default.
• W2034885923 hasConcept C104317684 @default.
• W2034885923 hasConcept C126322002 @default.
• W2034885923 hasConcept C134018914 @default.
• W2034885923 hasConcept C149011108 @default.
• W2034885923 hasConcept C181199279 @default.
• W2034885923 hasConcept C185592680 @default.
• W2034885923 hasConcept C2777476445 @default.
• W2034885923 hasConcept C2777905771 @default.
• W2034885923 hasConcept C2778722691 @default.
• W2034885923 hasConcept C2779907587 @default.
• W2034885923 hasConcept C36201501 @default.
• W2034885923 hasConcept C44312359 @default.
• W2034885923 hasConcept C538909803 @default.
• W2034885923 hasConcept C55493867 @default.
• W2034885923 hasConcept C71924100 @default.
• W2034885923 hasConcept C86803240 @default.
• W2034885923 hasConcept C87644729 @default.
• W2034885923 hasConcept C98274493 @default.
• W2034885923 hasConceptScore W2034885923C10146269 @default.
• W2034885923 hasConceptScore W2034885923C104317684 @default.
• W2034885923 hasConceptScore W2034885923C126322002 @default.
• W2034885923 hasConceptScore W2034885923C134018914 @default.
• W2034885923 hasConceptScore W2034885923C149011108 @default.
• W2034885923 hasConceptScore W2034885923C181199279 @default.
• W2034885923 hasConceptScore W2034885923C185592680 @default.
• W2034885923 hasConceptScore W2034885923C2777476445 @default.
• W2034885923 hasConceptScore W2034885923C2777905771 @default.
• W2034885923 hasConceptScore W2034885923C2778722691 @default.
• W2034885923 hasConceptScore W2034885923C2779907587 @default.
• W2034885923 hasConceptScore W2034885923C36201501 @default.
• W2034885923 hasConceptScore W2034885923C44312359 @default.
• W2034885923 hasConceptScore W2034885923C538909803 @default.
• W2034885923 hasConceptScore W2034885923C55493867 @default.
• W2034885923 hasConceptScore W2034885923C71924100 @default.
• W2034885923 hasConceptScore W2034885923C86803240 @default.
• W2034885923 hasConceptScore W2034885923C87644729 @default.
• W2034885923 hasConceptScore W2034885923C98274493 @default.
• W2034885923 hasIssue "12" @default.
• W2034885923 hasLocation W20348859231 @default.
• W2034885923 hasLocation W20348859232 @default.

• next