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- W2034885961 abstract "Whole-cell patch clamp recording and immunohistochemistry were used to investigate the expression of P2X receptors on rat parasympathetic ganglion neurons of the otic, sphenopalatine, submandibular, intracardiac and paratracheal ganglia. Neurons from all five ganglia responded to ATP with a rapidly activating, sustained inward current. Neurons of intracardiac and paratracheal ganglia were insensitive to alphabeta-meATP, while all neurons in the otic and some neurons of sphenopalatine and submandibular ganglia responded. Lowering pH potentiated ATP responses in neurons from all five ganglia. Co-application of Zn(2+) potentiated ATP responses in intracardiac, paratracheal and submandibular ganglion neurons. Immunohistochemistry revealed strong and specific staining for the P2X(2) subunit in all five ganglia and strong P2X(3) staining in otic, sphenopalatine and submandibular ganglia. In conclusion, there is heterogeneity in P2X receptor expression in different parasympathetic ganglia of the rat, but the predominant receptor subtypes involved appear to be homomeric P2X(2) and heteromeric P2X(2/3)." @default.
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- W2034885961 date "2005-04-01" @default.
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- W2034885961 title "Differential expression of P2X receptors on neurons from different parasympathetic ganglia" @default.
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- W2034885961 doi "https://doi.org/10.1016/j.neuropharm.2004.12.021" @default.
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