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- W2034886137 endingPage "3406" @default.
- W2034886137 startingPage "3397" @default.
- W2034886137 abstract "Abstract Ras proteins are critical nodes in cellular signaling that integrate inputs from activated cell surface receptors and other stimuli to modulate cell fate through a complex network of effector pathways. Oncogenic RAS mutations are found in ∼ 25% of human cancers and are highly prevalent in hematopoietic malignancies. Because of their structural and biochemical properties, oncogenic Ras proteins are exceedingly difficult targets for rational drug discovery, and no mechanism-based therapies exist for cancers with RAS mutations. This article reviews the properties of normal and oncogenic Ras proteins, the prevalence and likely pathogenic role of NRAS, KRAS, and NF1 mutations in hematopoietic malignancies, relevant animal models of these cancers, and implications for drug discovery. Because hematologic malignancies are experimentally tractable, they are especially valuable platforms for addressing the fundamental question of how to reverse the adverse biochemical output of oncogenic Ras in cancer." @default.
- W2034886137 created "2016-06-24" @default.
- W2034886137 creator A5023734568 @default.
- W2034886137 creator A5024722625 @default.
- W2034886137 creator A5088220792 @default.
- W2034886137 date "2012-10-25" @default.
- W2034886137 modified "2023-10-11" @default.
- W2034886137 title "Targeting oncogenic Ras signaling in hematologic malignancies" @default.
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