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- W2034886323 abstract "The synthesis and pharmacological activity of partial retro-inverso modified rat atrial natriuretic factor (rANF) analogs is described. The route to these compounds utilized a combination of solution and solid-phase methods. The analogs prepared all contain a reversed amide bond (psi[NHCO]) at the Ser 25 to Phe26 linkage. This bond has been suggested to play a key role in the metabolic inactivation of ANF. The analogs are of comparable potency to the endogenous peptide rANF1-28 in binding to cultured rat vascular smooth muscle cells, in relaxing serotonin contracted rabbit aortic rings, and as natriuretic/diuretic agents in anesthetized rats. None of the peptides has an extended duration of action in vivo." @default.
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- W2034886323 date "2009-01-12" @default.
- W2034886323 modified "2023-09-27" @default.
- W2034886323 title "Synthesis and activity of partial retro-inverso modified atrial natriuretic factor analogs" @default.
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- W2034886323 doi "https://doi.org/10.1111/j.1399-3011.1988.tb00925.x" @default.
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