FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034887357> ?p ?o ?g. }

• W2034887357 endingPage "14613" @default.
• W2034887357 startingPage "14606" @default.
• W2034887357 abstract "West Nile virus has spread rapidly across the United States, and there is currently no approved human vaccine or therapy to prevent or treat disease. Passive immunization with antibodies against the envelope protein represents a promising means to provide short-term prophylaxis and treatment for West Nile virus infection. In this study, we identified a panel of 11 unique human single-chain variable region antibody fragments (scFvs) that bind the envelope protein of West Nile virus. Selected scFvs were converted to Fc fusion proteins (scFv-Fcs) and were tested in mice for their ability to prevent lethal West Nile virus infection. Five of these scFv-Fcs, 11, 15, 71, 85, and 95, protected 100% of mice from death when given prior to infection with virus. Two of them, 11 and 15, protected 80% of mice when given at days 1 and 4 after infection. In addition, four of the scFv-Fcs cross-neutralized dengue virus, serotype 2. Binding assays using yeast surface display demonstrated that all of our scFvs bind to sites within domains I and II of West Nile virus envelope protein. These recombinant human scFvs are potential candidates for immunoprophylaxis and therapy of flavivirus infections." @default.
• W2034887357 created "2016-06-24" @default.
• W2034887357 creator A5000780125 @default.
• W2034887357 creator A5012738713 @default.
• W2034887357 creator A5015888849 @default.
• W2034887357 creator A5022173812 @default.
• W2034887357 creator A5027591123 @default.
• W2034887357 creator A5036239296 @default.
• W2034887357 creator A5037535789 @default.
• W2034887357 creator A5046563222 @default.
• W2034887357 creator A5046619240 @default.
• W2034887357 creator A5049433553 @default.
• W2034887357 creator A5055991332 @default.
• W2034887357 creator A5065157313 @default.
• W2034887357 creator A5070153307 @default.
• W2034887357 creator A5074206319 @default.
• W2034887357 creator A5075988461 @default.
• W2034887357 creator A5080880738 @default.
• W2034887357 date "2005-12-15" @default.
• W2034887357 modified "2023-10-18" @default.
• W2034887357 title "Protective and Therapeutic Capacity of Human Single-Chain Fv-Fc Fusion Proteins against West Nile Virus" @default.
• W2034887357 cites W133347907 @default.
• W2034887357 cites W1572786643 @default.
• W2034887357 cites W1755753723 @default.
• W2034887357 cites W1975490802 @default.
• W2034887357 cites W1980525323 @default.
• W2034887357 cites W1980840323 @default.
• W2034887357 cites W1993098170 @default.
• W2034887357 cites W2004274451 @default.
• W2034887357 cites W2017680126 @default.
• W2034887357 cites W2024853038 @default.
• W2034887357 cites W2040998612 @default.
• W2034887357 cites W2045428863 @default.
• W2034887357 cites W2060749694 @default.
• W2034887357 cites W2061042843 @default.
• W2034887357 cites W2077030137 @default.
• W2034887357 cites W2084534408 @default.
• W2034887357 cites W2096953096 @default.
• W2034887357 cites W2105390335 @default.
• W2034887357 cites W2117739952 @default.
• W2034887357 cites W2117772378 @default.
• W2034887357 cites W2121756311 @default.
• W2034887357 cites W2122593398 @default.
• W2034887357 cites W2129706355 @default.
• W2034887357 cites W2135387914 @default.
• W2034887357 cites W2142758749 @default.
• W2034887357 cites W2147054984 @default.
• W2034887357 cites W2148741876 @default.
• W2034887357 cites W2150516802 @default.
• W2034887357 cites W2152930176 @default.
• W2034887357 cites W2153537922 @default.
• W2034887357 cites W2154804319 @default.
• W2034887357 cites W2161329181 @default.
• W2034887357 cites W2471207461 @default.
• W2034887357 cites W4237675909 @default.
• W2034887357 cites W4239341883 @default.
• W2034887357 doi "https://doi.org/10.1128/jvi.79.23.14606-14613.2005" @default.
• W2034887357 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1287547" @default.
• W2034887357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16282460" @default.
• W2034887357 hasPublicationYear "2005" @default.
• W2034887357 type Work @default.
• W2034887357 sameAs 2034887357 @default.
• W2034887357 citedByCount "113" @default.
• W2034887357 countsByYear W20348873572012 @default.
• W2034887357 countsByYear W20348873572013 @default.
• W2034887357 countsByYear W20348873572014 @default.
• W2034887357 countsByYear W20348873572015 @default.
• W2034887357 countsByYear W20348873572016 @default.
• W2034887357 countsByYear W20348873572017 @default.
• W2034887357 countsByYear W20348873572018 @default.
• W2034887357 countsByYear W20348873572019 @default.
• W2034887357 countsByYear W20348873572020 @default.
• W2034887357 countsByYear W20348873572021 @default.
• W2034887357 countsByYear W20348873572022 @default.
• W2034887357 crossrefType "journal-article" @default.
• W2034887357 hasAuthorship W2034887357A5000780125 @default.
• W2034887357 hasAuthorship W2034887357A5012738713 @default.
• W2034887357 hasAuthorship W2034887357A5015888849 @default.
• W2034887357 hasAuthorship W2034887357A5022173812 @default.
• W2034887357 hasAuthorship W2034887357A5027591123 @default.
• W2034887357 hasAuthorship W2034887357A5036239296 @default.
• W2034887357 hasAuthorship W2034887357A5037535789 @default.
• W2034887357 hasAuthorship W2034887357A5046563222 @default.
• W2034887357 hasAuthorship W2034887357A5046619240 @default.
• W2034887357 hasAuthorship W2034887357A5049433553 @default.
• W2034887357 hasAuthorship W2034887357A5055991332 @default.
• W2034887357 hasAuthorship W2034887357A5065157313 @default.
• W2034887357 hasAuthorship W2034887357A5070153307 @default.
• W2034887357 hasAuthorship W2034887357A5074206319 @default.
• W2034887357 hasAuthorship W2034887357A5075988461 @default.
• W2034887357 hasAuthorship W2034887357A5080880738 @default.
• W2034887357 hasBestOaLocation W20348873571 @default.
• W2034887357 hasConcept C104317684 @default.
• W2034887357 hasConcept C123894998 @default.
• W2034887357 hasConcept C159047783 @default.
• W2034887357 hasConcept C159654299 @default.
• W2034887357 hasConcept C196594336 @default.
• W2034887357 hasConcept C203014093 @default.

• next