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• W2034887663 abstract "In the present study we investigated the association of the RANTES (regulated upon activation, normal T-cell expressed and secreted) −28C&gt;G and −403G&gt;A promoter polymorphisms with the concentration of serum RANTES and CAD (coronary artery disease) in Korean men. We included 553 male CAD patients with (n=176) or without (n=377) Type 2 diabetes, aged 40–65 years with previous myocardial infarction (∼50%) or angiographically confirmed CAD (∼50%), and 416 aged-matched healthy male controls. The main outcome measures were the OR (odds ratio) of CAD risk and the serum RANTES concentration evaluated by sandwich ELISA. Although the RANTES −28C&gt;G genotype had no significant association with CAD risk, the presence of the minor allele of the RANTES −403G&gt;A single nucleotide polymorphism was associated with a lower risk of CAD {OR 0.70 [95% CI (confidence interval) 0.54–0.92], P=0.011} after adjusting for age, BMI (body mass index), cigarette smoking and alcohol consumption. Serum RANTES concentrations were significantly associated with the −403G&gt;A genotype in controls (G/G: 44.7±3.3 ng/ml, G/A: 36.5±2.0 ng/ml, A/A: 28.7±2.5 ng/ml; P&lt;0.001), non-diabetic CAD patients (G/G: 50.9±3.0 ng/ml, G/A: 42.2±2.6 ng/ml, A/A: 41.3±4.4 ng/ml; P&lt;0.05) and diabetic CAD patients (G/G: 58.5±3.5 ng/ml, G/A: 49.6±4.1 ng/ml, A/A: 42.2±4.3 ng/ml; P&lt;0.05); however, such associations were not observed in the subgroup of CAD patients taking lipid-lowering medication. Moreover, serum RANTES was positively correlated with C-reactive protein (r=0.289, P&lt;0.001) and platelet counts (r=0.253, P&lt;0.001). The results of the present study demonstrate that the RANTES −403A allele is associated with lower serum RANTES concentrations and consequently with reduced CAD risk." @default.
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• W2034887663 date "2007-09-12" @default.
• W2034887663 modified "2023-10-11" @default.
• W2034887663 title "The <i>RANTES</i> −403G&gt;A promoter polymorphism in Korean men: association with serum RANTES concentration and coronary artery disease" @default.
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• W2034887663 doi "https://doi.org/10.1042/cs20070014" @default.
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