FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034887943> ?p ?o ?g. }

• W2034887943 endingPage "64" @default.
• W2034887943 startingPage "57" @default.
• W2034887943 abstract "BACKGROUND. Preoperative chemoradiation is the standard treatment for locally advanced rectal cancer. However, it is uncertain whether pretreatment clinical stage, degree of response to neoadjuvant treatment, or pathologic stage is the most reliable predictor of outcome. This study compared various staging elements and treatment-related variables to identify which factors or combination of factors reliably prognosticates disease-free survival in rectal cancer patients receiving neoadjuvant combined modality therapy. METHODS. From a prospectively maintained single institution database, 342 consecutive patients with locally advanced rectal cancer staged by endorectal ultrasound were identified. Patients underwent rectal resection 4 to 8 weeks after a 5.5-week course of pelvic radiotherapy/concurrent chemotherapy. The degree of tumor regression was histologically graded on each resected specimen using a previously reported response scale of 0% to 100%. Predictive models of disease-free survival were created utilizing available pretherapy and postoperative staging elements in addition to the degree of tumor regression noted histologically. Model accuracy was measured and compared by concordance index, with 95% confidence interval (CI). RESULTS. Stratifying patients by degree of tumor regression predicted outcome with a concordance index of 0.65 (95% CI, 0.59–0.71), which was significantly better than models using preoperative stage elements (concordance index of 0.54; 95% CI, 0.50–0.58). However, the model found to be most predictive of disease-free survival stratified patients by final pathologic T classification and N classification elements, with a concordance index of 0.75 (95% CI, 0.70–0.80). CONCLUSIONS. Tumor response to preoperative therapy is a strong predictor of disease-free survival. However, outcome is most accurately estimated by final pathologic stage, which is influenced by both preoperative stage and response to therapy. Cancer 2008. © 2008 American Cancer Society." @default.
• W2034887943 created "2016-06-24" @default.
• W2034887943 creator A5002800513 @default.
• W2034887943 creator A5011642439 @default.
• W2034887943 creator A5013157364 @default.
• W2034887943 creator A5051277222 @default.
• W2034887943 creator A5054489256 @default.
• W2034887943 creator A5057039700 @default.
• W2034887943 creator A5060512446 @default.
• W2034887943 creator A5082001484 @default.
• W2034887943 creator A5087201995 @default.
• W2034887943 creator A5088893766 @default.
• W2034887943 date "2008-07-01" @default.
• W2034887943 modified "2023-10-07" @default.
• W2034887943 title "Pathologic stage is most prognostic of disease‐free survival in locally advanced rectal cancer patients after preoperative chemoradiation" @default.
• W2034887943 cites W1585172067 @default.
• W2034887943 cites W1964532421 @default.
• W2034887943 cites W1972987731 @default.
• W2034887943 cites W1977468182 @default.
• W2034887943 cites W1986549937 @default.
• W2034887943 cites W1988071481 @default.
• W2034887943 cites W1993259888 @default.
• W2034887943 cites W1994527599 @default.
• W2034887943 cites W2023623711 @default.
• W2034887943 cites W2033660144 @default.
• W2034887943 cites W2040879252 @default.
• W2034887943 cites W2050742455 @default.
• W2034887943 cites W2063655425 @default.
• W2034887943 cites W2078849228 @default.
• W2034887943 cites W2084330270 @default.
• W2034887943 cites W2095439981 @default.
• W2034887943 cites W2113353705 @default.
• W2034887943 cites W2124468792 @default.
• W2034887943 cites W2124695217 @default.
• W2034887943 cites W2124886112 @default.
• W2034887943 cites W2125452425 @default.
• W2034887943 cites W2127433346 @default.
• W2034887943 cites W2127699440 @default.
• W2034887943 cites W2135398482 @default.
• W2034887943 cites W2138405942 @default.
• W2034887943 cites W2143655828 @default.
• W2034887943 cites W2146340574 @default.
• W2034887943 cites W4249691405 @default.
• W2034887943 doi "https://doi.org/10.1002/cncr.23516" @default.
• W2034887943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18442099" @default.
• W2034887943 hasPublicationYear "2008" @default.
• W2034887943 type Work @default.
• W2034887943 sameAs 2034887943 @default.
• W2034887943 citedByCount "223" @default.
• W2034887943 countsByYear W20348879432012 @default.
• W2034887943 countsByYear W20348879432013 @default.
• W2034887943 countsByYear W20348879432014 @default.
• W2034887943 countsByYear W20348879432015 @default.
• W2034887943 countsByYear W20348879432016 @default.
• W2034887943 countsByYear W20348879432017 @default.
• W2034887943 countsByYear W20348879432018 @default.
• W2034887943 countsByYear W20348879432019 @default.
• W2034887943 countsByYear W20348879432020 @default.
• W2034887943 countsByYear W20348879432021 @default.
• W2034887943 countsByYear W20348879432022 @default.
• W2034887943 countsByYear W20348879432023 @default.
• W2034887943 crossrefType "journal-article" @default.
• W2034887943 hasAuthorship W2034887943A5002800513 @default.
• W2034887943 hasAuthorship W2034887943A5011642439 @default.
• W2034887943 hasAuthorship W2034887943A5013157364 @default.
• W2034887943 hasAuthorship W2034887943A5051277222 @default.
• W2034887943 hasAuthorship W2034887943A5054489256 @default.
• W2034887943 hasAuthorship W2034887943A5057039700 @default.
• W2034887943 hasAuthorship W2034887943A5060512446 @default.
• W2034887943 hasAuthorship W2034887943A5082001484 @default.
• W2034887943 hasAuthorship W2034887943A5087201995 @default.
• W2034887943 hasAuthorship W2034887943A5088893766 @default.
• W2034887943 hasBestOaLocation W20348879431 @default.
• W2034887943 hasConcept C121608353 @default.
• W2034887943 hasConcept C126322002 @default.
• W2034887943 hasConcept C126838900 @default.
• W2034887943 hasConcept C141071460 @default.
• W2034887943 hasConcept C146357865 @default.
• W2034887943 hasConcept C151730666 @default.
• W2034887943 hasConcept C160798450 @default.
• W2034887943 hasConcept C2778292576 @default.
• W2034887943 hasConcept C2780091936 @default.
• W2034887943 hasConcept C2781074409 @default.
• W2034887943 hasConcept C44249647 @default.
• W2034887943 hasConcept C509974204 @default.
• W2034887943 hasConcept C526805850 @default.
• W2034887943 hasConcept C530470458 @default.
• W2034887943 hasConcept C71924100 @default.
• W2034887943 hasConcept C86803240 @default.
• W2034887943 hasConceptScore W2034887943C121608353 @default.
• W2034887943 hasConceptScore W2034887943C126322002 @default.
• W2034887943 hasConceptScore W2034887943C126838900 @default.
• W2034887943 hasConceptScore W2034887943C141071460 @default.
• W2034887943 hasConceptScore W2034887943C146357865 @default.
• W2034887943 hasConceptScore W2034887943C151730666 @default.
• W2034887943 hasConceptScore W2034887943C160798450 @default.
• W2034887943 hasConceptScore W2034887943C2778292576 @default.
• W2034887943 hasConceptScore W2034887943C2780091936 @default.

• next