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- W2034888064 abstract "The proliferative T lymphocyte responses to two different mumps antigen preparations, S (nucleocapsid) and V (viral envelope), were characterized. Eight patients with Type 1 (insulin-dependent) diabetes mellitus were all found to be responders to S and V mumps antigen. Among the 64 healthy individuals. 52 were classified as responders to the S antigen and 50 as responders to the V antigen. No difference was found between T lymphocytes from Type 1 diabetic patients and those from healthy individuals as regards the effeet of indomethacin on the mumps-specific response. The majority of the mumps-specific T lymphocytes seemed to he restricted by epitopes on the HLA-DR molecules. The frequency of mumps antigen-reactive T lymphocytes (ARTL) was found to be low when the response was restricted by DR3-associated elements, and high when it was restricted by DR4-associated elements, compared to the frequency of ARTL when other DR-associated elements restricted the mumps-specific response. For the majority of the individuals tested, the DR-associated hypo- and hyper-responsiveness was found with both the S andthe V mumps antigens." @default.
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- W2034888064 date "1985-11-01" @default.
- W2034888064 modified "2023-09-24" @default.
- W2034888064 title "HLA Control of the Proliferative T Lymphocyte Response to Antigenic Determinants on Mumps Virus." @default.
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- W2034888064 doi "https://doi.org/10.1111/j.1365-3083.1985.tb01910.x" @default.
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