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• W2034890539 startingPage "6384" @default.
• W2034890539 abstract "Environmental pollutants polychlorinated biphenyls (PCBs), especially dioxin-like PCBs, cause oxidative stress and associated toxic effects, including cancer and possibly atherosclerosis. We previously reported that PCB 126, the most potent dioxin-like PCB congener, not only decreases antioxidants such as hepatic selenium (Se), Se-dependent glutathione peroxidase, and glutathione (GSH) but also increases levels of the antiatherosclerosis enzyme paraoxonase 1 (PON1) in liver and serum. To probe the interconnection of these three antioxidant systems, Se, GSH, and PON1, we examined the influence of varying levels of dietary Se and N-acetylcysteine (NAC), a scavenger of reactive oxygen species (ROS) and precursor for GSH synthesis, on PON1 in the absence and presence of PCB 126 exposure. Male Sprague-Dawley rats, fed diets with differing Se levels (0.02, 0.2, or 2 ppm) or NAC (1%), were treated with a single intraperitoneal injection of corn oil or various doses of PCB 126 and euthanized 2 weeks later. PCB 126 significantly increased liver PON1 mRNA, protein level and activity, and serum PON1 activity in all dietary groups but did not consistently increase thiobarbituric acid levels (thiobarbituric acid reactive substances, TBARS), an indicator of lipid oxidation and oxidative stress, in liver or serum. Inadequate (high or low) dietary Se decreased baseline and PCB 126-induced aryl hydrocarbon receptor (AhR) expression but further increased PCB 126-induced cytochrome P450 1A1 (CYP1A1) expression, the enzyme believed to be the cause for PCB 126-induced oxidative stress. In addition, a significant inverse relationship was observed not only between dietary Se levels and PON1 mRNA and PON1 activity but also with TBARS levels in the liver, suggesting significant antioxidant protection from dietary Se. NAC lowered serum baseline TBARS levels in controls and increased serum PON1 activity but lowered liver PON1 activities in animals treated with 1 μmol/kg PCB 126, suggesting antioxidant activity by NAC primarily in serum. These results also show an unexpected predominantly inverse relationship between Se or NAC and PON1 during control and PCB 126 exposure conditions. These interactions should be further explored in the development of dietary protection regimens." @default.
• W2034890539 created "2016-06-24" @default.
• W2034890539 creator A5000212434 @default.
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• W2034890539 date "2013-05-04" @default.
• W2034890539 modified "2023-10-12" @default.
• W2034890539 title "Dietary antioxidants (selenium and N-acetylcysteine) modulate paraoxonase 1 (PON1) in PCB 126-exposed rats" @default.
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• W2034890539 cites W1503933262 @default.
• W2034890539 cites W1527742671 @default.
• W2034890539 cites W1530602360 @default.
• W2034890539 cites W166231251 @default.
• W2034890539 cites W1916475046 @default.
• W2034890539 cites W1936968156 @default.
• W2034890539 cites W1964392512 @default.
• W2034890539 cites W1966597352 @default.
• W2034890539 cites W1971936300 @default.
• W2034890539 cites W1975835742 @default.
• W2034890539 cites W1976004420 @default.
• W2034890539 cites W1981557788 @default.
• W2034890539 cites W1983310681 @default.
• W2034890539 cites W1986320245 @default.
• W2034890539 cites W1986962632 @default.
• W2034890539 cites W1988339232 @default.
• W2034890539 cites W1991689589 @default.
• W2034890539 cites W1994370086 @default.
• W2034890539 cites W1995317658 @default.
• W2034890539 cites W2000847748 @default.
• W2034890539 cites W2001110632 @default.
• W2034890539 cites W2002637963 @default.
• W2034890539 cites W2003187293 @default.
• W2034890539 cites W2005838165 @default.
• W2034890539 cites W2012985897 @default.
• W2034890539 cites W2013065759 @default.
• W2034890539 cites W2013131201 @default.
• W2034890539 cites W2014524132 @default.
• W2034890539 cites W2016366656 @default.
• W2034890539 cites W2018057558 @default.
• W2034890539 cites W2018061302 @default.
• W2034890539 cites W2020102728 @default.
• W2034890539 cites W2020865273 @default.
• W2034890539 cites W2023068131 @default.
• W2034890539 cites W2026131954 @default.
• W2034890539 cites W2034546275 @default.
• W2034890539 cites W2034879947 @default.
• W2034890539 cites W2040888701 @default.
• W2034890539 cites W2041839476 @default.
• W2034890539 cites W2042585992 @default.
• W2034890539 cites W2048088059 @default.
• W2034890539 cites W2049061129 @default.
• W2034890539 cites W2050601245 @default.
• W2034890539 cites W2053628531 @default.
• W2034890539 cites W2054178406 @default.
• W2034890539 cites W2058510622 @default.
• W2034890539 cites W2059286422 @default.
• W2034890539 cites W2061333433 @default.
• W2034890539 cites W2067568257 @default.
• W2034890539 cites W2080786953 @default.
• W2034890539 cites W2088720117 @default.
• W2034890539 cites W2090682099 @default.
• W2034890539 cites W2092352193 @default.
• W2034890539 cites W2093175823 @default.
• W2034890539 cites W2094305716 @default.
• W2034890539 cites W2095543063 @default.
• W2034890539 cites W2101658474 @default.
• W2034890539 cites W2108958614 @default.
• W2034890539 cites W2119250245 @default.
• W2034890539 cites W2126039319 @default.
• W2034890539 cites W2128466839 @default.
• W2034890539 cites W2129978542 @default.
• W2034890539 cites W2137365670 @default.
• W2034890539 cites W2144161407 @default.
• W2034890539 cites W2156621340 @default.
• W2034890539 cites W2162450994 @default.
• W2034890539 cites W2163602949 @default.
• W2034890539 cites W2164486763 @default.
• W2034890539 cites W2164701049 @default.
• W2034890539 cites W2165292984 @default.
• W2034890539 cites W2166990706 @default.
• W2034890539 cites W2170807824 @default.
• W2034890539 cites W2399940392 @default.
• W2034890539 cites W4211158689 @default.
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• W2034890539 doi "https://doi.org/10.1007/s11356-013-1690-1" @default.
• W2034890539 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3769429" @default.
• W2034890539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23644946" @default.
• W2034890539 hasPublicationYear "2013" @default.
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