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• W2034893482 abstract "Growth/differentiation factor-10 (GDF-10) is a TGF-β family member highly related to bone morphogenetic protein-3. In order to determine the biological function of GDF-10, we carried out a detailed analysis of the expression pattern of GDF-10 and characterized GDF-10-null mice that we generated by gene targeting. During embryogenesis GDF-10 is expressed prominently in developing skeletal structures both in the craniofacial region and in the vertebral column. In adult animals, GDF-10 is expressed at high levels in the brain, where GDF-10 is localized primarily to cells in the Purkinje cell layer of the cerebellum, and in the uterus, where the expression levels of GDF-10 are regulated both during the menstrual cycle and during pregnancy. Despite the high levels of GDF-10 expression in these tissues, we found no obvious abnormalities in GDF-10-knockout mice with respect to the development of these tissues. These findings suggest either that GDF-10 plays no regulatory role in these tissues or that its function is redundant with that of other growth factor-like molecules." @default.
• W2034893482 created "2016-06-24" @default.
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• W2034893482 date "1999-08-01" @default.
• W2034893482 modified "2023-10-14" @default.
• W2034893482 title "Characterization of GDF-10 Expression Patterns and Null Mice" @default.
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• W2034893482 doi "https://doi.org/10.1006/dbio.1999.9326" @default.
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