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- W2034896261 abstract "Decline of peak viremia during acute HIV-1 infection occurs prior to the development of vigorous adaptive immunity and the level of decline correlates inversely with rate of AIDS progression, implicating a potential role for the innate immune response in determining disease outcome. Natural Killer (NK) cells are critical both in the early control of various viral infections but also play a critical role in inducing a vigorous antiviral adaptive immune response. The combined expression of the activating NK cell receptor KIR3DS1 and its presumed ligand HLA-B Bw4-80I has been associated with slow progression to AIDS, however it is uncertain whether subjects with this genotype exhibit qualitatively different patterns of NK cell expansions and contractions during acute infection that may contribute to differences in patterning of the adaptive immune response. This presentation will highlight our recent findings demonstrating that NK cells play a role in both promoting pathogenic events as well as protecting against disease progression in the presence of protective KIR/HLA genotypes in HIV infection." @default.
- W2034896261 created "2016-06-24" @default.
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- W2034896261 date "2009-06-01" @default.
- W2034896261 modified "2023-09-26" @default.
- W2034896261 title "124 NK cells: friends or foes?" @default.
- W2034896261 doi "https://doi.org/10.1097/01.qai.0000351081.04956.24" @default.
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