FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034899778> ?p ?o ?g. }

• W2034899778 endingPage "114" @default.
• W2034899778 startingPage "109" @default.
• W2034899778 abstract "Infants of diabetic mothers frequently have polycythemia, elevated serum erythropoietin concentrations, and decreased serum iron and ferritin concentrations, likely representing a redistribution of fetal iron into erythrocytes to support augmented fetal hemoglobin synthesis. We hypothesized that fetal liver, heart, and brain iron concentrations are also reduced in these infants. After obtaining autopsy tissue from infants who had died before 7 days of age, we measured liver, heart, and brain iron concentrations using atomic absorption spectrophotometry. Seven infants of diabetic mothers and seven gestational age-matched control infants were studied. All infants of diabetic mothers had pancreatic islet cell hyperplasia, indicating fetal hyperglycemia and hyperinsulinemia. Liver iron concentrations in the infants of diabetic mothers were 6.6% of control values (489.0±154.4 vs 7379.7±1473.8 μg/gm dry tissue weight (mean±SEM); p<0.001), heart iron concentrations were 43.9% of control values (124.7±20.5 vs 284.1±34.8 μg/gm dry tissue weight; p<0.002), and brain iron concentrations were 60.6% of control values (106.1±13.7 vs 175.2±10.7 μg/gm dry tissue weight; p<0.003). Heart and brain iron concentrations were directly correlated with liver iron concentrations (r=0.80 for both; p<0.001) and indicated that hepatic iron was >75% depleted before heart and brain iron reduction. We conclude that severely affected infants of diabetic mothers have reduced liver, heart, and brain iron concentrations. The role of tissue iron deficiency in the genesis of the abnormal clinical findings in these infants deserves further consideration. Infants of diabetic mothers frequently have polycythemia, elevated serum erythropoietin concentrations, and decreased serum iron and ferritin concentrations, likely representing a redistribution of fetal iron into erythrocytes to support augmented fetal hemoglobin synthesis. We hypothesized that fetal liver, heart, and brain iron concentrations are also reduced in these infants. After obtaining autopsy tissue from infants who had died before 7 days of age, we measured liver, heart, and brain iron concentrations using atomic absorption spectrophotometry. Seven infants of diabetic mothers and seven gestational age-matched control infants were studied. All infants of diabetic mothers had pancreatic islet cell hyperplasia, indicating fetal hyperglycemia and hyperinsulinemia. Liver iron concentrations in the infants of diabetic mothers were 6.6% of control values (489.0±154.4 vs 7379.7±1473.8 μg/gm dry tissue weight (mean±SEM); p<0.001), heart iron concentrations were 43.9% of control values (124.7±20.5 vs 284.1±34.8 μg/gm dry tissue weight; p<0.002), and brain iron concentrations were 60.6% of control values (106.1±13.7 vs 175.2±10.7 μg/gm dry tissue weight; p<0.003). Heart and brain iron concentrations were directly correlated with liver iron concentrations (r=0.80 for both; p<0.001) and indicated that hepatic iron was >75% depleted before heart and brain iron reduction. We conclude that severely affected infants of diabetic mothers have reduced liver, heart, and brain iron concentrations. The role of tissue iron deficiency in the genesis of the abnormal clinical findings in these infants deserves further consideration." @default.
• W2034899778 created "2016-06-24" @default.
• W2034899778 creator A5008864422 @default.
• W2034899778 creator A5012332396 @default.
• W2034899778 creator A5013511447 @default.
• W2034899778 creator A5030242411 @default.
• W2034899778 creator A5050067583 @default.
• W2034899778 creator A5050389739 @default.
• W2034899778 date "1992-07-01" @default.
• W2034899778 modified "2023-10-16" @default.
• W2034899778 title "Iron deficiency of liver, heart, and brain in newborn infants of diabetic mothers" @default.
• W2034899778 cites W1970563834 @default.
• W2034899778 cites W1993593650 @default.
• W2034899778 cites W2000031904 @default.
• W2034899778 cites W2001674706 @default.
• W2034899778 cites W2002417499 @default.
• W2034899778 cites W2029331530 @default.
• W2034899778 cites W2035944180 @default.
• W2034899778 cites W2043871545 @default.
• W2034899778 cites W2051943760 @default.
• W2034899778 cites W2058390030 @default.
• W2034899778 cites W2061128469 @default.
• W2034899778 cites W2061235268 @default.
• W2034899778 cites W2095916091 @default.
• W2034899778 cites W2145328262 @default.
• W2034899778 cites W2148841816 @default.
• W2034899778 cites W2331721697 @default.
• W2034899778 cites W2414911081 @default.
• W2034899778 doi "https://doi.org/10.1016/s0022-3476(05)82554-5" @default.
• W2034899778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1625067" @default.
• W2034899778 hasPublicationYear "1992" @default.
• W2034899778 type Work @default.
• W2034899778 sameAs 2034899778 @default.
• W2034899778 citedByCount "190" @default.
• W2034899778 countsByYear W20348997782012 @default.
• W2034899778 countsByYear W20348997782013 @default.
• W2034899778 countsByYear W20348997782014 @default.
• W2034899778 countsByYear W20348997782015 @default.
• W2034899778 countsByYear W20348997782016 @default.
• W2034899778 countsByYear W20348997782017 @default.
• W2034899778 countsByYear W20348997782018 @default.
• W2034899778 countsByYear W20348997782019 @default.
• W2034899778 countsByYear W20348997782020 @default.
• W2034899778 countsByYear W20348997782021 @default.
• W2034899778 countsByYear W20348997782022 @default.
• W2034899778 countsByYear W20348997782023 @default.
• W2034899778 crossrefType "journal-article" @default.
• W2034899778 hasAuthorship W2034899778A5008864422 @default.
• W2034899778 hasAuthorship W2034899778A5012332396 @default.
• W2034899778 hasAuthorship W2034899778A5013511447 @default.
• W2034899778 hasAuthorship W2034899778A5030242411 @default.
• W2034899778 hasAuthorship W2034899778A5050067583 @default.
• W2034899778 hasAuthorship W2034899778A5050389739 @default.
• W2034899778 hasConcept C126322002 @default.
• W2034899778 hasConcept C134018914 @default.
• W2034899778 hasConcept C172680121 @default.
• W2034899778 hasConcept C2777417653 @default.
• W2034899778 hasConcept C2778248108 @default.
• W2034899778 hasConcept C2778319317 @default.
• W2034899778 hasConcept C2778917026 @default.
• W2034899778 hasConcept C2779234561 @default.
• W2034899778 hasConcept C54355233 @default.
• W2034899778 hasConcept C555293320 @default.
• W2034899778 hasConcept C66322754 @default.
• W2034899778 hasConcept C71924100 @default.
• W2034899778 hasConcept C86803240 @default.
• W2034899778 hasConceptScore W2034899778C126322002 @default.
• W2034899778 hasConceptScore W2034899778C134018914 @default.
• W2034899778 hasConceptScore W2034899778C172680121 @default.
• W2034899778 hasConceptScore W2034899778C2777417653 @default.
• W2034899778 hasConceptScore W2034899778C2778248108 @default.
• W2034899778 hasConceptScore W2034899778C2778319317 @default.
• W2034899778 hasConceptScore W2034899778C2778917026 @default.
• W2034899778 hasConceptScore W2034899778C2779234561 @default.
• W2034899778 hasConceptScore W2034899778C54355233 @default.
• W2034899778 hasConceptScore W2034899778C555293320 @default.
• W2034899778 hasConceptScore W2034899778C66322754 @default.
• W2034899778 hasConceptScore W2034899778C71924100 @default.
• W2034899778 hasConceptScore W2034899778C86803240 @default.
• W2034899778 hasIssue "1" @default.
• W2034899778 hasLocation W20348997781 @default.
• W2034899778 hasLocation W20348997782 @default.
• W2034899778 hasOpenAccess W2034899778 @default.
• W2034899778 hasPrimaryLocation W20348997781 @default.
• W2034899778 hasRelatedWork W1812355893 @default.
• W2034899778 hasRelatedWork W1820664237 @default.
• W2034899778 hasRelatedWork W1980882008 @default.
• W2034899778 hasRelatedWork W2025975065 @default.
• W2034899778 hasRelatedWork W2395909070 @default.
• W2034899778 hasRelatedWork W2910240063 @default.
• W2034899778 hasRelatedWork W3011728705 @default.
• W2034899778 hasRelatedWork W3199821407 @default.
• W2034899778 hasRelatedWork W4292831968 @default.
• W2034899778 hasRelatedWork W2340251845 @default.
• W2034899778 hasVolume "121" @default.
• W2034899778 isParatext "false" @default.
• W2034899778 isRetracted "false" @default.
• W2034899778 magId "2034899778" @default.

• next