Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034900419> ?p ?o ?g. }
- W2034900419 endingPage "42" @default.
- W2034900419 startingPage "35" @default.
- W2034900419 abstract "Intercellular adhesion molecule-1 (ICAM-1) plays a fundamental role during liver inflammation. In fact, weak ICAM-1 expression is physiologically restricted to the endothelium of portal vessels and to sinusoidal lining cells, but it becomes markedly evident on sinusoidal lining cells and at the surface of hepatocytes during inflammatory liver diseases. The aim of this study was to evaluate the behaviour of soluble ICAM-1 (sICAM-1) in chronic hepatitis C (CH-C) patients with persistently normal aminotransferase in comparison with patients with CH-C and elevated aminotransferase, and its changes during alpha-interferon (IFN) therapy. Immunohistochemical localization of ICAM-1 was also performed on liver tissue specimens of both groups.Sixty subjects were divided into 3 groups: group A included 19 patients with CH-C and persistently normal aminotransferase; group B included 21 patients with CH-C and persistently elevated aminotransferase levels, and group C included 20 healthy subjects representing the control group. The first two groups were treated with recombinant alpha-IFN 2b at a dose of 6 MU 3 times a week for 3 months and followed up with 3 MU 3 times a week for another 3 months.Baseline values of serum ICAM-1 in groups A and B were significantly higher than those in group C (p < 0.0001). The median baseline value of sICAM-1 in group A (525.0 ng/ml) was lower than that of group B (561.0 ng/ml), but the difference was not statistically significant. Furthermore, there was a trend toward higher ICAM-1 values as histological severity increased (Mantel-Haenszel chi(2) 8.8, p < 0.003). Post-treatment sICAM-1 serum values showed a marked decrease in both groups, but only among responder patients, while ICAM-1 levels were unchanged in non-responders. Immunohistochemical localization showed no staining for ICAM-1 in normal liver specimens, while there was a quite similar staining for ICAM-1 in the two groups of patients, consistent with an inflammatory process.This study shows that circulating ICAM-1 levels in most patients with CH-C and persistently normal aminotransferase are higher than those in a control group and the fact that ICAM-1 molecules are also expressed on the hepatocyte membrane suggests that they could play an important role, in association with other molecules, in the intercellular adhesion processes during the induction and maintenance phases of the immune response. In both groups, only patients responding to alpha-IFN therapy showed a marked decrease in serum ICAM-1 below baseline values." @default.
- W2034900419 created "2016-06-24" @default.
- W2034900419 creator A5028162881 @default.
- W2034900419 creator A5047903927 @default.
- W2034900419 creator A5058091052 @default.
- W2034900419 creator A5070243247 @default.
- W2034900419 creator A5082733849 @default.
- W2034900419 creator A5088747314 @default.
- W2034900419 creator A5089251537 @default.
- W2034900419 creator A5090620646 @default.
- W2034900419 date "2003-02-10" @default.
- W2034900419 modified "2023-09-27" @default.
- W2034900419 title "Circulating Intercellular Adhesion Molecule-1 in Chronic Hepatitis C Patients with Normal or Elevated Aminotransferase before and after Alpha-Interferon Treatment" @default.
- W2034900419 cites W101370422 @default.
- W2034900419 cites W120764934 @default.
- W2034900419 cites W1550207052 @default.
- W2034900419 cites W1610454879 @default.
- W2034900419 cites W1669190732 @default.
- W2034900419 cites W1975947881 @default.
- W2034900419 cites W1979843985 @default.
- W2034900419 cites W1980596251 @default.
- W2034900419 cites W1989208868 @default.
- W2034900419 cites W2017300018 @default.
- W2034900419 cites W2024880904 @default.
- W2034900419 cites W2031141548 @default.
- W2034900419 cites W2042400975 @default.
- W2034900419 cites W2044065359 @default.
- W2034900419 cites W2047568894 @default.
- W2034900419 cites W2047766116 @default.
- W2034900419 cites W2053862365 @default.
- W2034900419 cites W2053876819 @default.
- W2034900419 cites W2066713395 @default.
- W2034900419 cites W2069296829 @default.
- W2034900419 cites W2069696551 @default.
- W2034900419 cites W2074794585 @default.
- W2034900419 cites W2080168089 @default.
- W2034900419 cites W2086945989 @default.
- W2034900419 cites W2087139768 @default.
- W2034900419 cites W2106278600 @default.
- W2034900419 cites W2110633655 @default.
- W2034900419 cites W2113296405 @default.
- W2034900419 cites W2115956200 @default.
- W2034900419 cites W2116925086 @default.
- W2034900419 cites W2118047427 @default.
- W2034900419 cites W2119676105 @default.
- W2034900419 cites W2149727205 @default.
- W2034900419 cites W2156466962 @default.
- W2034900419 cites W2159954692 @default.
- W2034900419 cites W2165295967 @default.
- W2034900419 cites W2170559052 @default.
- W2034900419 cites W2183194066 @default.
- W2034900419 cites W2325158670 @default.
- W2034900419 cites W2396869539 @default.
- W2034900419 cites W313048209 @default.
- W2034900419 doi "https://doi.org/10.1159/000068122" @default.
- W2034900419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12566697" @default.
- W2034900419 hasPublicationYear "2003" @default.
- W2034900419 type Work @default.
- W2034900419 sameAs 2034900419 @default.
- W2034900419 citedByCount "4" @default.
- W2034900419 countsByYear W20349004192013 @default.
- W2034900419 crossrefType "journal-article" @default.
- W2034900419 hasAuthorship W2034900419A5028162881 @default.
- W2034900419 hasAuthorship W2034900419A5047903927 @default.
- W2034900419 hasAuthorship W2034900419A5058091052 @default.
- W2034900419 hasAuthorship W2034900419A5070243247 @default.
- W2034900419 hasAuthorship W2034900419A5082733849 @default.
- W2034900419 hasAuthorship W2034900419A5088747314 @default.
- W2034900419 hasAuthorship W2034900419A5089251537 @default.
- W2034900419 hasAuthorship W2034900419A5090620646 @default.
- W2034900419 hasConcept C126322002 @default.
- W2034900419 hasConcept C134018914 @default.
- W2034900419 hasConcept C141071460 @default.
- W2034900419 hasConcept C16224149 @default.
- W2034900419 hasConcept C178790620 @default.
- W2034900419 hasConcept C185592680 @default.
- W2034900419 hasConcept C185946421 @default.
- W2034900419 hasConcept C203014093 @default.
- W2034900419 hasConcept C2522874641 @default.
- W2034900419 hasConcept C2775944032 @default.
- W2034900419 hasConcept C2776178377 @default.
- W2034900419 hasConcept C2776914184 @default.
- W2034900419 hasConcept C2776992346 @default.
- W2034900419 hasConcept C2909179924 @default.
- W2034900419 hasConcept C2909375385 @default.
- W2034900419 hasConcept C3020491458 @default.
- W2034900419 hasConcept C49453240 @default.
- W2034900419 hasConcept C64943373 @default.
- W2034900419 hasConcept C71924100 @default.
- W2034900419 hasConcept C84416704 @default.
- W2034900419 hasConcept C90924648 @default.
- W2034900419 hasConceptScore W2034900419C126322002 @default.
- W2034900419 hasConceptScore W2034900419C134018914 @default.
- W2034900419 hasConceptScore W2034900419C141071460 @default.
- W2034900419 hasConceptScore W2034900419C16224149 @default.
- W2034900419 hasConceptScore W2034900419C178790620 @default.
- W2034900419 hasConceptScore W2034900419C185592680 @default.
- W2034900419 hasConceptScore W2034900419C185946421 @default.