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- W2034905968 endingPage "435" @default.
- W2034905968 startingPage "429" @default.
- W2034905968 abstract "Toll-like receptor (TLR) adjuvants are capable of driving T cell immunity. The TLR4 agonist LPS activates antigen-presenting cells through myeloid differentiation primary response gene 88 (MyD88) and TIR domain-containing adaptor inducing interferon-beta (TRIF)-dependent signaling pathways, initiating CD4 T helper cell clonal expansion and differentiation. Lipopolysaccharide (LPS) supports the development of diverse T helper (Th) lineages depending on the tissue microenvironment. For instance, peripheral immunization with LPS drives Th1 priming in lymphoid tissue and Th17 priming in the gut. This could be due to commensal bacteria inducing Th17-stabilizing cytokines within the intestinal lamina propria. Here, we detail how the response to LPS stimulates CD4 T cell priming in lymphoid tissue and the intestinal mucosa. How this knowledge might be exploited to target specific features of T cell immunity by vaccine adjuvants is also considered." @default.
- W2034905968 created "2016-06-24" @default.
- W2034905968 creator A5021846790 @default.
- W2034905968 creator A5027034727 @default.
- W2034905968 date "2010-11-01" @default.
- W2034905968 modified "2023-10-16" @default.
- W2034905968 title "Educating CD4 T cells with vaccine adjuvants: lessons from lipopolysaccharide" @default.
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