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- W2034921411 abstract "This study assesses the capacity of a new hydrophobically modified polysaccharide -hydroxypropyl cellulose-methyl methacrylate - to control drug release in semisolid formulations. The dispersed systems contain the new polymer, Igepal CO520 as surfactant and theophylline as model drug at three concentrations (0.5, 1 and 1.5%, w/w). Drug release study shows that the systems containing 0.5% (w/w) of drug have faster release and higher diffusion coefficient than the other two concentrations. These results can be explained by two different structures (relaxed and structured) found from a rheological point of view. Also, this paper compares two different devices for testing drug release and diffusion. It has been obtained more reliable and reproducible results with Enhancer Cell respect to Franz diffusion cell. In both cases, Fickian diffusion was the mechanism predominant for all systems. Finally, the utility of this polymer has been demonstrated to make three-dimensional gel structure and control theophylline release from systems in topical application." @default.
- W2034921411 created "2016-06-24" @default.
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- W2034921411 date "2013-01-01" @default.
- W2034921411 modified "2023-10-16" @default.
- W2034921411 title "Drug diffusion from disperse systems with a hydrophobically modified polysaccharide: Enhancer® vs Franz cells" @default.
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- W2034921411 doi "https://doi.org/10.1016/j.carbpol.2012.09.005" @default.
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