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• W2034921462 startingPage "141" @default.
• W2034921462 abstract "The purpose of this study was to review potential, physiological, hormonal and neuronal mechanisms that may mediate the sleep changes. This paper investigates the literatures regarding the activity of the hypothalamic-pituitary-adrenal (HPA) axis, one of the main neuroendocrine stress systems during sleep in order to identify relations between stress and sleep disorder and the treatment of stress-induced insomnia. Sleep and wakefulness are regulated by the aminergic, cholinergic brainstem and hypothalamic systems. Activation of the HPA and/or the sympathetic nervous systems results in wakefulness and these hormones including corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), cortisol or corticosterone, noradrenaline, and adrenaline, are associated with attention and arousal. Stress-related insomnia leads to a vicious circle by activating the HPA system. An awareness of the close interaction between sleep and stress systems is emerging and the hypothalamus is now recognized as a key center for sleep regulation, with hypothalamic neurontransmitter systems providing the framework for therapeutic advances. An updated understanding of these systems may allow researchers to elucidate neural mechanisms of sleep disorder and to develop effective intervention for sleep disorder." @default.
• W2034921462 created "2016-06-24" @default.
• W2034921462 creator A5016022345 @default.
• W2034921462 creator A5060807298 @default.
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• W2034921462 date "2012-12-30" @default.
• W2034921462 modified "2023-10-12" @default.
• W2034921462 title "Stress and Sleep Disorder" @default.
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• W2034921462 doi "https://doi.org/10.5607/en.2012.21.4.141" @default.
• W2034921462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3538178" @default.
• W2034921462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23319874" @default.
• W2034921462 hasPublicationYear "2012" @default.
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